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Turmeric

IN THIS ARTICLE

Are there any interactions with medications?



Medications for diabetes (Antidiabetes drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Turmeric might decrease blood sugar in people with type 2 diabetes. Diabetes medications are also used to lower blood sugar. Taking turmeric along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.



Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Turmeric might slow blood clotting. Taking turmeric along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.



Sulfasalazine (Azulfidine EN-Tabs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Turmeric might increase how much sulfasalazine (Azulfidine EN-Tabs) the body absorbs. Taking turmeric while taking sulfasalazine (Azulfidine EN-Tabs) might increase the effects and side effects of sulfasalazine (Azulfidine EN-Tabs).



Talinolol
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Turmeric might decrease how much talinolol the body absorbs. Taking turmeric while taking talinolol might decrease the effects and side effects of talinolol.



Docetaxel (Docefrez, Taxotere)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Turmeric might increase how much docetaxel (Docefrex, Taxotere) the body absorbs. Taking turmeric while taking docetaxel (Docefrex, Taxotere) might increase the effects and side effects of docetaxel (Docefrex, Taxotere).



Estrogens
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Large amounts of turmeric might have some of the same effects as estrogen. However, large amounts of turmeric are not as strong as estrogen pills. Taking turmeric along with estrogen pills might decrease the effects of estrogen pills.

Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.



Medications changed by the liver (Cytochrome P450 1A1 (CYP1A1) substrates)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Turmeric might decrease how quickly the liver breaks down some medications. Taking turmeric along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking turmeric talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include chlorzoxazone (Lorzone), theophylline, and bufuralol.



Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Turmeric might decrease how quickly the liver breaks down some medications. Taking turmeric along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking turmeric talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), zileuton (Zyflo), zolmitriptan (Zomig), and others.



Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Turmeric might decrease how quickly the liver breaks down some medications. Taking turmeric along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking turmeric talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include some calcium channel blockers (diltiazem, nicardipine, verapamil), chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), glucocorticoids, alfentanil (Alfenta), cisapride (Propulsid), fentanyl (Sublimaze), lidocaine (Xylocaine), losartan (Cozaar), fexofenadine (Allegra), midazolam (Versed), and others.



Medications moved by pumps in cells (P-Glycoprotein Substrates)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Some medications are moved by pumps in cells. Turmeric might make these pumps less active and increase how much of some medications get absorbed by the body. This might increase the amount of some medications in the body, which could lead to more side effects. But there is not enough information to know if this is a big concern.

Some medications that are moved by these pumps include some chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), protease inhibitors (amprenavir, indinavir, nelfinavir, saquinavir), H2 antagonists (cimetidine, ranitidine), some calcium channel blockers (diltiazem, verapamil), digoxin, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.



Norfloxacin (Noroxin)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Turmeric might increase how much norfloxacin (Noroxin) the body absorbs. Taking turmeric while taking norfloxacin (Noroxin) might increase the effects and side effects of norfloxacin (Noroxin).



Paclitaxel (Abraxane, Onxol)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Turmeric might increase how much paclitaxel (Abraxane, Onxol) the body absorbs. Taking turmeric while taking paclitaxel (Abraxane, Onxol) might increase the effects and side effects of paclitaxel (Abraxane, Onxol). However, there is not enough information to know if this is a big concern.

Dosing considerations for Turmeric.

ADULTS

BY MOUTH:
  • For high cholesterol: 1.4 grams of turmeric extract in two divided doses daily for 3 months has been used.
  • For itching (pruritus): 1500 mg of turmeric in three divided doses daily for 8 weeks has been used. Also, a specific product containing turmeric extract (C3 Complex, Sami Labs LTD) plus black pepper or long pepper has been used daily for 4 weeks.
  • For osteoarthritis: 500 mg of a non-commercial turmeric product four times daily for 4-6 weeks has been used. 500 mg of a specific turmeric extract (Turmacin, Natural Remedies Pvt. Ltd.) has been used twice daily for 6 weeks (89721). 500 mg of a specific turmeric extract (Meriva, Indena) containing turmeric and phosphatidylcholine has been used twice daily for 2-3 months. Other combination products have also been used.

CHILDREN

BY MOUTH:
  • For high cholesterol: 1.4 grams of turmeric extract in two divided doses daily for 3 months has been used in children at least 15 years-old.

Report Problems to the Food and Drug Administration

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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.



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