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Ulcerative Colitis

Ulcerative Colitis Overview

Ulcerative colitis (UC) is an acute or chronic inflammation of the membrane lining the colon (the large intestine or bowel). Ulcerative colitis causes inflammation and sores (ulcers), in the top layers of the lining of the large intestine. Ulcerative colitis rarely affects the small intestine except for the lower section, called the ileum.

The inflammation makes the colon empty frequently, causing diarrhea. Ulcers form in places where the inflammation has killed the cells linking the colon. The ulcers bleed and produce pus and mucus.

Symptoms of ulcerative colitis include abdominal pain, diarrhea, rectal bleeding, the recurrent urge to have a bowel movement (tenesmus), lack of appetite, fever, and fatigue.

Abdominal pain, diarrhea, and bloody bowel movements are the hallmark of the disease.

Ulcerative colitis is one of the inflammatory bowel diseases (IBD), the other is Crohn's disease.

  • Ulcerative colitis may be difficult to diagnose because its symptoms may mimic other intestinal disorders such as irritable bowel syndrome.

  • Crohn's disease differs from ulcerative colitis because it causes inflammation deeper within the intestinal wall, and may occur anywhere in the digestive tract, from the mouth to the anus, and is patchy in nature. While it most often occurs in the small intestine there can be scattered lesions throughout the gastrointestinal tract. Ulcerative colitis affects only the colon and progresses continuously from the rectum to potentially involve the rest of the colon.
  • There are an estimated 2 million people in the United States who suffer from inflammatory bowel disease. Ulcerative colitis is generally found in younger people, before they reach age 30. But the disease can also occur in people in their 60s and later in life. It affects both men and women equally, and there is a familial predisposition to its development. Those of Jewish heritage have a higher incidence of ulcerative colitis.


Next: Ulcerative Colitis Causes »

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Ulcerative Colitis

Proctitis Overview

Proctitis is defined as inflammation of your anus (the opening) and lining of your rectum (lower part of the intestine leading to the anus). Symptoms can vary greatly. You may at first have only minor problems. Proctitis affects the last 6 inches of the rectum and can cause the following:

  • Pain during a bowel movement
  • Soreness in your anal and rectal area
  • Feeling that you didn't completely empty your bowels after a bowel movement
  • Involuntary spasms and cramping during bowel movements
  • Bleeding, and possibly a discharge
Proctitis can last a short time or become a chronic condition (last for weeks or months or longer).

Proctitis Causes

Proctitis has many causes, but sexually transmitted diseases (STDs) are the most common. Gonorrhea, syphilis, herpes, anal warts, and chlamy...

Read the Proctitis article »



Read What Your Physician is Reading on eMedicine

Ulcerative Colitis »

Ulcerative colitis (UC) is an idiopathic chronic inflammatory disorder limited to the colon. 

Read More on eMedicine »

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