Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Drugs in this class include diclofenac(Cataflam, Voltaren), ibuprofen(Advil, Motrin), ketoprofen(Orudis), naproxen(Aleve, Naprosyn), piroxicam(Feldene), etodolac(Lodine), indomethacin(Indocin), oxaprozin(Daypro), nabumetone(Relafen), and meloxicam(Mobic).
How NSAIDs work: NSAIDs prevent the body from producing prostaglandins, which have been identified as a cause of pain and inflammation. NSAIDs prevent this by inhibiting the cyclooxygenase(COX) enzymesthat are important in the formation of prostaglandins by cells. Several types of anti-inflammatory agents exist. Doctors recommend NSAIDs as the first type of medicine to try after they initially diagnose ankylosing spondylitis. Some of these drugs may be purchased without a prescription.