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June 19, 2013
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Understanding Antidepressant Medications (cont.)

Medical Author:
Mary L Windle, PharmD
Pharmacy Editor:
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD

Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

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Bupropion (Wellbutrin, Wellbutrin SR, Wellbutrin XL)

  • Bupropion (Wellbutrin, Wellbutrin SR, Wellbutrin XL) may increase the blood levels and/or risk of toxicity of the following drugs:
    • Alcohol or other drugs that depress the central nervous system such as drugs taken for insomnia
    • SSRIs
    • TCAs
    • Beta blockers such as propranolol (Inderal)
    • Antiarrhythmic drugs such as flecainide (Tambocor) or propafenone (Rythmol)
    • warfarin (Coumadin)
  • The following drugs may increase bupropion blood levels or toxicity:
    • Other drugs that increase seizure risk
    • amantadine (Symmetrel)
    • levodopa (Sinemet)
    • carbamazepine (Tegretol)
    • MAOIs
    • ritonavir (Norvir)

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Toxicity, Antidepressant »

Tricyclic antidepressants (TCAs) were one of the most important causes of mortality resulting from poisoning until 1993 and continue to be responsible for more deaths per prescription than all the other antidepressants put together.

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