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May 23, 2013
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Understanding Antidepressant Medications (cont.)

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Duloxetine (Cymbalta)

  • Duloxetine (Cymbalta) may increase the blood levels and/or risk of toxicity of the following drugs:
    • Alcohol or other drugs that depress the central nervous system such as drugs taken for insomnia
    • Antiarrhythmic drugs such as flecainide (Tambocor) or propafenone (Rythmol)
    • Phenothiazines such as thioridazine (Mellaril)
    • TCAs
    • MAOIs
    • warfarin (Coumadin)
  • The following drugs may increase duloxetine blood levels or toxicity:

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Read What Your Physician is Reading on Medscape

Toxicity, Antidepressant »

Tricyclic antidepressants (TCAs) were one of the most important causes of mortality resulting from poisoning until 1993 and continue to be responsible for more deaths per prescription than all the other antidepressants put together.

Read More on Medscape Reference »


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