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Understanding Antidepressant Medications (cont.)

Nefazodone (Serzone)

  • Nefazodone (Serzone) may increase the blood levels and/or risk of toxicity of the following drugs:
    • Alcohol or other drugs that depress the central nervous system such as drugs taken for insomnia
    • buspirone (Buspar)
    • carbamazepine (Tegretol)
    • cisapride (Propulsid)
    • cyclosporine (Neoral, Sandimmune)
    • digoxin (Lanoxin)
    • pimozide (Orap)
    • thioridazine (Mellaril)
    • triazolam (Halcion)
    • St. John's wort
    • SSRIs
    • TCAs
    • Drugs that may cause abnormal heart rhythms (check with the doctor or pharmacist)
    • Drugs indicated to treat high cholesterol such as simvastatin (Zocor) or atorvastatin (Lipitor)
  • The following drugs may increase nefazodone blood levels or toxicity:
    • buspirone (Buspar)
    • sibutramine (Meridia)
    • sumatriptan (Imitrex) or other similar drugs for migraine headache
Medically Reviewed by a Doctor on 7/18/2014
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