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Understanding Antidepressant Medications (cont.)

Venlafaxine (Effexor)

  • Venlafaxine (Effexor) may alter the blood levels and/or risk of toxicity of the following drugs:
    • clozapine
    • (Clozaril)
    • desipramine (Norpramin)
    • haloperidol (Haldol)
    • indinavir
    • (Crixivan)
    • SSRIs, sibutramine (Meridia), sumatriptan (Imitrex), trazodone (Desyrel), and St. John's wort (These medications may increase the risk for serotonin syndrome—symptoms include hypertension, fever, muscle tremor, or confusion.)
    • warfarin (Coumadin)
  • The following drugs may increase venlafaxine blood levels or toxicity:
    • cimetidine (Tagamet)
    • MAOIs
    • SSRIs, nefazodone (Serzone), St. John's wort, and venlafaxine (These medications may increase the risk for serotonin syndrome - symptoms include hypertension, fever, muscle tremor, or confusion.)
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