Understanding Antidepressant Medications (cont.)
IN THIS ARTICLE
Tricyclic antidepressants (TCAs) are often prescribed in severe cases of depression or when SSRI medications do not work.
Tricyclic antidepressants include:
How do TCAs work?
TCAs block the uptake of serotonin and norepinephrine, thereby providing higher levels of these neurotransmitters at the brain receptor site. Besides increasing norepinephrine and serotonin, amoxapine also increases the neurotransmitter dopamine.
Who should not use these medications?
Elderly: Elderly individuals require lower doses. Elderly individuals are more susceptible to sedative effects and may feel faint when standing up, therefore increasing the risk of falls and injuries.
Children: The following TCAs are approved in the United States for treating adolescents with depression who are older than 12 years:
Medically Reviewed by a Doctor on 12/10/2015
Mary L Windle, PharmD
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