Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Individuals with seizure disorders (Do not use bupropion and maprotiline.)
Individuals taking MAOIs (Do not use duloxetine, maprotiline, and venlafaxine.)
Other contraindications include the following:
Bupropion (Wellbutrin, Wellbutrin SR, Wellbutrin XL): Individuals with bulimia or anorexia nervosa, or those in the process of withdrawal from alcohol or sedatives should not take bupropion.
Duloxetine (Cymbalta): Individuals with uncontrolled narrow-angle glaucoma should not take duloxetine.
Maprotiline (Ludiomil), mirtazapine (Remeron), nefazodone (Serzone), and trazodone
(Desyrel): Individuals who have experienced a recent heart attack should not take these medications.
Nefazodone (Serzone): Individuals should not take nefazodone if they have liver impairment or are currently using cisapride (Propulsid), pimozide (Orap), carbamazepine (Tegretol), or triazolam (Halcion).
Atypical antidepressants are administered orally.
Mirtazapine (Remeron SolTab) is a tablet that dissolves when placed in the mouth instead of swallowing with water.
Some atypical antidepressants are available as sustained-release tablets or capsules and should only be swallowed whole (do not crush, divide, or chew).
Abrupt discontinuation of some atypical antidepressants, such as duloxetine, may cause withdrawal-like symptoms such as agitation, anxiety, confusion, dizziness, headache, and insomnia. Ask a doctor or pharmacist if the medication dose should be gradually tapered down to avoid these symptoms.
Children: Safety and efficacy of duloxetine, bupropion, maprotiline, mirtazapine, nefazodone, and trazodone have not been established in children younger than 18 years.
Drug or food interactions: Tell the doctor what medications are currently being taken because many drugs interact with atypical antidepressants. Do not take any nonprescription or herbal medications without first consulting the doctor or pharmacist. The following are examples of interactions, but they do not represent a complete list.
Tricyclic antidepressants (TCAs) were one of the most important causes of mortality resulting from poisoning until 1993 and continue to be responsible for more deaths per prescription than all the other antidepressants put together.