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Understanding Antidepressant Medications (cont.)

Bupropion (Wellbutrin, Wellbutrin SR, Wellbutrin XL)

  • Bupropion (Wellbutrin, Wellbutrin SR, Wellbutrin XL) may increase the blood levels and/or risk of toxicity of the following drugs:
    • Alcohol or other drugs that depress the central nervous system such as drugs taken for insomnia
    • SSRIs
    • TCAs
    • Beta blockers such as propranolol (Inderal)
    • Antiarrhythmic drugs such as flecainide (Tambocor) or propafenone (Rythmol)
    • warfarin (Coumadin)
  • The following drugs may increase bupropion blood levels or toxicity:

Duloxetine (Cymbalta)

  • Duloxetine (Cymbalta) may increase the blood levels and/or risk of toxicity of the following drugs:
    • Alcohol or other drugs that depress the central nervous system such as drugs taken for insomnia
    • Antiarrhythmic drugs such as flecainide (Tambocor) or propafenone (Rythmol)
    • Phenothiazines such as thioridazine (Mellaril)
    • TCAs
    • MAOIs
    • warfarin (Coumadin)
  • The following drugs may increase duloxetine blood levels or toxicity:
Medically Reviewed by a Doctor on 12/10/2015
Medical Author:
Pharmacy Editor:

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