Prostaglandins

• Generic/trade names: Latanoprost (Xalatan), bimatoprost (Lumigan), travoprost (Travatan), unoprostone (Rescula)
  
  
• How prostaglandins work: These drugs work near the drainage area within the eye to improve aqueous outflow, which, in turn, lowers intraocular pressure (IOP).
  
  
• Who should not use these medications
  
  
  • Persons allergic to prostaglandin eyedrops
    
    
  • Persons with inflammation (swelling) of the eye

• Use: These drugs are given as eyedrops to the affected eye(s).
  
  
• Drug or food interactions: Eyedrops containing the preservative thimerosal form a crystal if administered at the same time. Wait at least 5 minutes between applications. If administered with pilocarpine eyedrops, wait at least 10 minutes—preferably, 1 hour—between applying the two drugs.
  
  
• Side effects: These eyedrops should not be used while wearing contact lenses. An increase in brown pigment in the iris and gradual changes in eye color may occur. Eyelash growth and pigmentation may increase. Skin on the eyelids and around the eyes may darken. Excessive tearing, eye pain, or lid crusting may occur. Burning, stinging, foreign-body sensation (something in the eye), blurred vision, and itching have also been observed.