Understanding Heartburn/GERD Medications (cont.)

Medical Author:

Mary L Windle, PharmD

Medical Editor:

Simmy Bank, MD, MB, ChB

Medical Editor:

Francisco Talavera, PharmD, PhD

Medical Editor:

BS Anand, MD

Sucralfate (Carafate) may be used initially to protect an irritated or inflamed esophagus.

How coating drugs work: This drug binds to proteins from secretions in the stomach and esophagus, which forms a substance that protects the lining of the stomach and esophagus.
Who should not use these medications: Individuals who have experienced an allergic reaction to this drug should not take it.
Use: Sucralfate must be taken 4 times a day on an empty stomach and at least 1 hour before meals.
Drug or food interactions: Sucralfate may decrease effects of ketoconazole (Nizoral), ciprofloxacin (Cipro), levofloxacin (Levaquin), tetracycline (Sumycin), phenytoin (Dilantin), warfarin (Coumadin), quinidine (Quinaglute, Cardioquin, Quinidex), and theophylline (SLO-BID, Theo-24, Theo-Dur, Uniphyl).
Side effects: Sucralfate should be used with caution in people with kidney failure because it contains aluminum, which may accumulate in the body. The drug often causes constipation.