Pineal gland hormones include melatonin and ramelteon (Rozerem).
How pineal gland hormones work: Melatonin is a hormone produced by the pineal gland (located in the brain) during the dark hours of the day-night cycle (circadian rhythm). Melatonin levels in the body are low during daylight hours. The pineal gland responds to darkness by increasing melatonin levels in the body. This process is thought to be integral to maintaining circadian rhythm. Ramelteon is a prescription drug that stimulates melatonin receptors. It promotes the onset of sleep and helps normalize circadian rhythm disorders. It is approved by the Food and Drug Administration for insomnia characterized by difficulty falling asleep.
Melatonin has been reported to be useful in the treatment of jet lag. Melatonin is believed to be effective when crossing 5 or more time zones and is less effective when traveling in westward direction. It is also used in the treatment of insomnia in elderly patients who are melatonin deficient and have trouble falling asleep. Melatonin has also been used for treatment of circadian rhythm sleep disorders in people who are blind and have no light perception. Melatonin is available as over-the-counter and is not approved by the FDA for sleep disorders as it is considered an alternative medicine. Caution is advised that variations in quality, purity, and quantity of active ingredient in natural pharmaceuticals make interpretation of clinical studies difficult and raises concerns about appropriate dose, drug interactions, and possible contaminants. Individual patients may or may not experience the reported benefits of melatonin. Slow-release melatonin products are reported to be less effective.
Who should not use these medications:
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