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Generally, the diagnosis can be accurately made during a physical examination without the benefit of any further laboratory support. It is important to distinguish vitiligo from a variety of other skin conditions in which pigment loss (leukoderma) may be a part. Some of these conditions are present at birth and may have a well established genetic cause, like albinism. Others may have easily treated infectious etiology, like the fungus infection tinea versicolor. Occasionally, in order to distinguish these disorders, it may be necessary to perform a skin biopsy.
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