zanamivir, Relenza Glossary of Terms

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Antiviral: An agent that kills a virus or that suppresses its ability to replicate and, hence, inhibits its capability to multiply and reproduce.
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Asthma: A common lung disorder in which inflammation causes the bronchi to swell and narrow the airways, creating breathing difficulties that may range from mild to life-threatening. Symptoms include shortness of breath, cough, wheezing, and chest tightness. The diagnosis of asthma is based on evidence of wheezing and is confirmed with breathing tests. Many allergens and irritants can precipitate attacks of asthma. Avoidance of precipitating factors can be helpful. Treatment may include lifestyle changes, activity reduction, allergy shots, and medications to prevent or reverse the bronchospasm.

Attenuated: Weakened, diluted, thinned, reduced, weakened, diminished.
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Breathing: The process of respiration, during which air is inhaled into the lungs through the mouth or nose due to muscle contraction and then exhaled due to muscle relaxation.

CDC: The Centers for Disease Control and Prevention, the US agency charged with tracking and investigating public health trends. A part of the US Public Health Services (PHS) under the Department of Health and Human Services (HHS), the CDC is based in Atlanta, Georgia. It publishes key health information, including weekly data on all deaths and diseases reported in the US and travelers' health advisories. The CDC also fields special rapid-response teams to halt epidemic diseases.

Cell: The basic structural and functional unit of any living thing. Each cell is a small container of chemicals and water wrapped in a membrane. There are 100 trillion cells in a human, and each contains all of the genetic information necessary to manufacture a human being. This information is encoded within the cell nucleus in 6 billion subunits of DNA called base pairs. These base pairs are packaged in 23 pairs of chromosomes, with 1 chromosome in each pair coming from each parent. Each of the 46 human chromosomes contains the DNA for thousands of individual genes.

Contraindication: A condition which makes a particular treatment or procedure potentially inadvisable. A contraindication may be absolute or relative.

• An absolute contraindication is a situation which makes a particular treatment or procedure absolutely inadvisable. In children, for example, aspirin is almost always contraindicated because of the danger that aspirin will cause Reye syndrome.

• A relative contraindication is a condition which makes a particular treatment or procedure possibly inadvisable. For example, X-rays in pregnancy are relatively contraindicated (because of concern for the developing fetus) unless the X-rays are absolutely necessary.

Cough: A rapid expulsion of air from the lungs, typically in order to clear the lung airways of fluids, mucus, or other material. Also known as tussis.

Diarrhea: A common condition that involves unusually frequent and liquid bowel movements. The opposite of constipation. There are many infectious and noninfectious causes of diarrhea. Persistent diarrhea is both uncomfortable and dangerous to the health because it can indicate an underlying infection and may mean that the body is not able to absorb some nutrients due to a problem in the bowels. Treatment includes drinking plenty of fluids to prevent dehydration and taking over-the-counter remedies. People with diarrhea that persists for more than a couple days, particularly small children or elderly people, should seek medical attention.

Dizziness: Painless head discomfort with many possible causes including disturbances of vision, the brain, balance (vestibular) system of the inner ear, and gastrointestinal system. Dizziness is a medically indistinct term which laypersons use to describe a variety of conditions ranging from lightheadedness, unsteadiness to vertigo.
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Ear: The hearing organ. There are three sections of the ear, according to the anatomy textbooks. They are the outer ear (the part we see along the sides of our head behind the temples), the middle ear, and the inner ear. But in terms of function, the ear has four parts: those three and the brain. Hearing thus involves all parts of the ear as well as the auditory cortex of the brain. The external ear helps concentrate the vibrations of air on the ear drum and make it vibrate. These vibrations are transmitted by a chain of little bones in the middle ear to the inner ear. There they stimulate the fibers of the auditory nerve to transmit impulses to the brain.
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Enzyme: A protein (or protein-based molecule) that speeds up a chemical reaction in a living organism. An enzyme acts as catalyst for specific chemical reactions, converting a specific set of reactants (called substrates) into specific products. Without enzymes, life as we know it would not exist.
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FDA: Food and Drug Administration.

Flu: Short for influenza. The flu is caused by viruses that infect the respiratory tract which are divided into three types, designated A, B, and C. Most people who get the flu recover completely in 1 to 2 weeks, but some people develop serious and potentially life-threatening medical complications, such as pneumonia. Much of the illness and death caused by influenza can be prevented by annual influenza vaccination.

Flu vaccine: The flu vaccination (influenza) is recommended for persons at high risk for serious complications from influenza virus infection.
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Generic: 1. The chemical name of a drug. 2. A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug may be sold. 3.A term referring to any drug marketed under its chemical name without advertising.

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Infection: The invasion and multiplication of microorganisms such as bacteria, viruses, and parasites that are not normally present within the body. An infection may cause no symptoms and be subclinical, or it may cause symptoms and be clinically apparent. An infection may remain localized, or it may spread through the blood or lymphatic vessels to become systemic (bodywide). Microorganisms that live naturally in the body are not considered infections. For example, bacteria that normally live within the mouth and intestine are not infections.

Influenza: The flu is caused by viruses that infect the respiratory tract which are divided into three types, designated A, B, and C. Most people who get the flu recover completely in 1 to 2 weeks, but some people develop serious and potentially life-threatening medical complications, such as pneumonia. Much of the illness and death caused by influenza can be prevented by annual influenza vaccination.

Nausea: Stomach queasiness, the urge to vomit. Nausea can be brought on by many causes, including systemic illnesses (such as influenza), medications, pain, and inner ear disease.

Nose: The external midline projection from the face. The purpose of the nose is to warm, clean, and humidify the air that a person breathes. In addition, it helps a person to smell and taste. The nose is divided into two passageways by a partition called the septum. Opening to these passageways are the nostrils. Bony projections, called turbinates, protrude into each breathing passage; they help to increase the surface area of the inside of the nose. There are three turbinates on each side of the nose (the inferior, middle, and superior turbinates). The sinuses are four paired air-filled chambers that empty into the nasal cavity.

Nursing: 1) Profession concerned with the provision of services essential to the maintenance and restoration of health by attending the needs of sick persons. 2) Feeding a infant at the breast.

Pregnancy: The state of carrying a developing embryo or fetus within the female body. This condition can be indicated by positive results on an over-the-counter urine test, and confirmed through a blood test, ultrasound, detection of fetal heartbeat, or an X-ray. Pregnancy lasts for about nine months, measured from the date of the woman's last menstrual period (LMP). It is conventionally divided into three trimesters, each roughly three months long.
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Pregnant: The state of carrying a developing fetus within the body.
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Prescription: A physician's order for the preparation and administration of a drug or device for a patient. A prescription has several parts. They include the superscription or heading with the symbol "R" or "Rx", which stands for the word recipe (meaning, in Latin, to take); the inscription, which contains the names and quantities of the ingredients; the subscription or directions for compounding the drug; and the signature which is often preceded by the sign "s" standing for signa (Latin for mark), giving the directions to be marked on the container.

Replication: A turning back, repetition, duplication, reproduction.

Respiratory: Having to do with respiration.

Sinusitis: Inflammation of the lining membrane in any of the hollow areas (sinuses) of the skull around the nose. Sinusitis may be caused by anything that interferes with air flow into the sinuses and the drainage of mucous out of the sinuses. The sinus openings, called ostia, may be obstructed by swelling of the tissue lining the ostia and adjacent nasal passage tissue; for example, from colds, allergies, and tissue irritants (nasal sprays, cocaine, cigarette smoke). Less commonly, sinuses can become obstructed by tumors or growths. Stagnated mucous then provides a perfect environment for bacterial infection. The common symptoms of sinusitis include headache; facial tenderness or pain; fever; cloudy, discolored nasal drainage; a feeling of nasal stuffiness; sore throat; and cough. Acute sinusitis is usually treated with antibiotic therapy. Chronic forms of sinusitis require long courses of antibiotics and may require a sinus drainage procedure.

Throat: The throat is the anterior (front) portion of the neck beginning at the back of the mouth, consisting anatomically of the pharynx and larynx. The throat contains the trachea and a portion of the esophagus.

Tubes: The "tubes" are medically known as the Fallopian tubes. There are two Fallopian tubes, one on each side, which transport the egg from the ovary to the uterus (the womb). The Fallopian tubes have small hair-like projections called cilia on the cells of the lining.
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Viral: Of or pertaining to a virus. For example, if a person has a viral rash, the rash was caused by a virus.

Virus: A microorganism that is smaller than a bacterium that cannot grow or reproduce apart from a living cell. A virus invades living cells and uses their chemical machinery to keep itself alive and to replicate itself. It may reproduce with fidelity or with errors (mutations); this ability to mutate is responsible for the ability of some viruses to change slightly in each infected person, making treatment difficult. Viruses cause many common human infections and are also responsible for a number of rare diseases. Examples of viral illnesses range from the common cold, which can be caused by one of the rhinoviruses, to AIDS, which is caused by HIV. Viruses may contain either DNA or RNA as their genetic material. Herpes simplex virus and the hepatitis B virus are DNA viruses. RNA viruses have an enzyme called reverse transcriptase that permits the usual sequence of DNA-to-RNA to be reversed so that the virus can make a DNA version of itself.
RNA viruses include HIV and hepatitis C virus. Researchers have grouped viruses together into several major families, based on their shape, behavior, and other characteristics. These include the herpes-viruses, adenoviruses, papovaviruses (including
the papillomaviruses), hepadnaviruses, poxviruses, and parvoviruses, among the DNA viruses. On the RNA virus side, major families include the picorna-viruses (including the rhinoviruses), calciviruses, paramyxoviruses, orthomyxoviruses, rhabdoviruses, filoviruses, and retroviruses. There are dozens
of smaller virus families within these major classifications. Many viruses are host specific, capable of infecting and causing disease in humans or specific animals only.

Viruses: Small living particles that can infect cells and change how the cells function. Infection with a virus can cause a person to develop symptoms. The disease and symptoms that are caused depend on the type of virus and the type of cells that are infected.