Skin Diseases: 15 Uncommon Skin Conditions

Reviewed on 4/26/2022

Peeling Skin Syndrome

Peeling skin syndrome resembles a lifelong sunburn.

It's like having lifelong sunburn, where you can pull up a sheet of the top layer of skin. It doesn't hurt, but your skin often itches and can get red, dry, thick, and blistered. Because it's genetic, this usually starts happening when you're quite young. Petroleum jelly, to soften skin, and medicines you put on warts and calluses might make it feel and look better, but other typical skin treatments don't help and could even be harmful.


Colored sweat is a sign of chromhidrosis.

Yellow, green, blue, brown, or black sweat? Yes! People with this condition have sweat glands that make too much lipofuscin (a pigment in human cells) or the lipofuscin is chemically different than normal. Colored sweat can appear in underarms, on the face, or in the dark circle around nipples. To stop it, you need to shut down the sweat glands. That could mean you apply a cream every day or get regular Botox shots.

Necrobiosis Lipoidica

Necrobiosis lipoidica causes skin ulcers, usually on the shins.

Small, raised, red spots -- usually on your shins -- slowly grow into larger, flatter patches. These have a red border and a shiny, yellowish center, and they probably won't go away. The skin is thin and may split easily to form slow-healing sores called ulcers that might lead to skin cancer. People who get this condition likely have diabetes or will have it soon. Your doctor may wait on treatment if you don't have ulcers yet.

Epidermolytic Ichthyosis

Epidermolytic ichthyosis causes red scaly skin on babies.

Babies with the disease may be born with red, blistered, raw-looking skin that's thick in places, injures easily, and gets inflamed. Thick, hard scales form in rows on the skin -- especially around creases of joints. A genetic test can tell for sure if you have the disease, which gets its name from the Greek word for "fish." Treatment isn't easy. Removing the scales often leaves skin fragile and prone to infection.

Morgellons Disease

Morgellons causes tiny fibers to appear erupted from the skin.

It feels like something is crawling on, stinging, or biting you. Some people report tiny fibers on their skin and problems with memory, mood, and concentration. Though certain studies suggest a possible link to infection, many scientists believe it's a mental health issue. You might have the mistaken belief that you're "infested." Your doctor will try to rule out other causes and may suggest therapy.

Erythropoietic Protoporphyria

Erythropoietic protoporphyria causes difficulty breaking down protoporphyrin in the skin.

People with this have changes (mutations) in their genes that make it hard for their body to process a light-sensitive chemical called protoporphyrin. It builds up in the top layers of skin and reacts to light from the sun as well as other sources. Your skin might tingle, itch, or burn If you don't cover up, it may blister and hurt intensely. Drugs, a type of vitamin A, and iron might help.

Fish Scale Disease

Buildup of keratin on the skin is a hallmark feature of ichthyosis vulgaris.

A slowdown of your skin's natural shedding causes a buildup of a protein called keratin that leads to dry skin, a flaky scalp, small fish-like scales (especially on your elbows and lower legs), and deep, painful cracks. Your skin may get darker, too. Ichthyosis vulgaris may be passed down from a parent or be related to an illness like cancer, thyroid disease, or HIV or AIDS. Living in a warm, humid place tends to make it better.

Eruptive Xanthomas

Eruptive xanthomas are waxy bumps that appear on the skin.

It can be alarming when these uneven, wart-like, waxy bumps suddenly show up on your skin, but they're not an infection, and they're not contagious. They're fatty deposits of cholesterol caused by very high levels of triglycerides, a type of fat in your blood. The bumps will usually clear up a few weeks after you start taking medicine and change your diet.


Leprosy causes reddish spots and swollen skin.

People who aren't naturally immune (most of us are) might get it from someone else -- or from handling an armadillo. Symptoms can take years to show up. Look for a rash or reddish spots, with swollen skin, and numbness in that spot or in a finger or toe. Your eyes could get very sensitive to light. Antibiotics usually cure it, and you should recover fully if you don't wait too long to treat it.

Blau Syndrome

Blau syndrome is a genetic condition that is driven by excess inflammation.

It usually starts before age 4 with a scaly rash on your trunk, arms, or legs, sometimes with hard bumps you can feel under your skin. This genetic disease makes your immune system overreact with too much inflammation. Many people with it also have arthritis and eye problems, and some get kidney disease. If neither of your parents have it, you may have a version called early-onset sarcoidosis.


Ingesting too much colloidal silver may cause argyria.

The bluish-gray skin color comes from tiny bits of silver that build up in your tissues. Colloidal silver, which some people take as a dietary supplement, can cause it, and it's usually permanent. Sunshine might make things worse. There's no evidence colloidal silver has any health benefits, and it may also slow absorption of medicines like thyroxine and antibiotics.

Xeroderma Pigmentosum (XP)

Xeroderma pigmentosum makes it harder for your body to repair damage to skin cells.

Xeroderma pigmentosum is a rare inherited condition in which your body isn’t able to repair itself from damage done by ultraviolet rays, including those from light bulbs. Any exposed skin including the eyes and tissues around the eyes are susceptible. Most people who have XP show symptoms before the age of ten, but early warning signs are freckles and dark spots before the age of two. This condition means you are at high risk for developing skin cancer including basal cell carcinoma, squamous cell carcinoma and melanoma. They also are at risk for cancer of the eye and surrounding tissues.

Acanthosis Nigricans

Acanthosis nigricans causes dark, thick, velvety patches of skin.

You may try to scrub off these dark, thick, velvety patches of skin, especially if they itch and smell bad. But it won't work. Elbows, knees, knuckles, and armpits are typical places to get them. The condition won't hurt you, but it can be a sign of other problems like obesity, diabetes, hormone problems, a drug reaction, or even cancer. Talk to your doctor.


Too much elastin causes a condition called elastoderma.

In some spots, your body may make too much elastin, a protein that gives skin strength and flexibility. Your skin won't spring back when stretched, and it sags and folds. It's not clear why this happens. You usually see it in the neck, arms, or legs -- especially around elbows and knees. Your doctor may cut away the loose skin, but the condition often returns.

Primary Cutaneous Amyloidosis

Cutaneous amyloidosis causes a buildup of amyloid in the skin.

This group of conditions is related by an abnormal protein called amyloid that builds up in your skin. Lichen amyloidosis is typically on your shins, thighs, feet, and forearms. It's itchy and looks like reddish-brown raised spots. Macular amyloidosis usually shows up between your shoulder blades or on your chest, with flat, dusty-colored patches. Nodular amyloidosis may appear on your body and face as firm, reddish bumps that don't itch.

Skin Diseases: 15 Uncommon Skin Conditions

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