©2018 WebMD, Inc. All rights reserved. eMedicineHealth does not provide medical advice, diagnosis or treatment. See Additional Information.

Androstenediol

What other names is Androstenediol known by?

1-Androstene-3beta, 17beta-diol; 4-AD; 4-Androstenediol; 4-Androstènediol; 4-Androstene 3, 17-diol; 4-androstene-3beta,17beta-diol; 5-AD; 5-Androstenediol; 5-Androstènediol; 5-androstene-3beta,17beta-diol; Androdiol; Androstènediol.

What is Androstenediol?

Androstenediol is a steroid. Steroids are chemical compounds that are distinguished by the way the carbon atoms are arranged. As a group, steroids include compounds that have powerful effects on the body, including the sex hormones called estrogen and testosterone.

Androstenediol used to be available as a dietary supplement. But under the Anabolic Steroid Control Act of 2004, it was reclassified as a schedule III controlled substance. This means androstenediol is available only as a prescription medicine, and physicians have to follow strict rules when prescribing it.

Androstenediol is used to increase the body's production of testosterone; increase energy; enhance recovery and growth from exercise; heighten sexual arousal and performance; and promote a greater sense of well-being.

The use of androstenediol has been banned by the National Collegiate Athletic Association (NCAA).

Possibly Ineffective for...

  • Athletic performance. Androstenediol does not seem to help increase muscle size or strength when taken by mouth for 12 weeks in connection with resistance training.

Insufficient Evidence to Rate Effectiveness for...

  • Increasing energy.
  • Improving body recovery and growth from exercise.
  • Heightening sexual arousal and performance.
  • Increasing a sense of well-being.
  • Other conditions.
More evidence is needed to rate the effectiveness of androstenediol for these uses.

How does Androstenediol work?

Androstenediol is a steroid hormone used by the body to make testosterone and estrogen.

Are there safety concerns?

Androstenediol is POSSIBLY UNSAFE for most people when taken by mouth. There is some concern that products can vary from what is listed on the label.

Women who take androstenediol might develop some male characteristics including deepening of the voice, facial hair growth, acne, abnormal menstrual periods, male-pattern baldness, thickening of the skin, and depression.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking androstenediol if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Heart disease: There is some concern that androstenediol might increase the risk of coronary heart disease.

Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Androstenediol can increase levels of hormones such estrone, estradiol, and testosterone. If you have any condition that might be made worse by exposure to these hormones, don't use androstenediol.

Prostate cancer and benign prostatic hypertrophy (BPH): Androstenediol can increase testosterone levels. There is also developing evidence that androstenediol might help prostate cancer cells grow. If you have a prostate condition, don't use androstenediol.

SLIDESHOW

Vitamin D Deficiency: How Much Vitamin D Is Enough? See Slideshow

Are there any interactions with medications?


EstrogensInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Androstenediol seems to increase estrogen levels in the body. Taking androstenediol along with estrogen pills might cause too much estrogen in the body.

Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.


TestosteroneInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.

The body changes androstenediol into testosterone. Taking androstenediol with a testosterone pill might cause there to be too much testosterone in the body. This might increase the chance of testosterone side effects.

Dosing considerations for Androstenediol.

The appropriate dose of androstenediol depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for androstenediol. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Health Solutions From Our Sponsors

Reviewed on 9/17/2019
References

Anderson, R. A., Bancroft, J., and Wu, F. C. The effects of exogenous testosterone on sexuality and mood of normal men. J Clin Endocrinol.Metab 1992;75(6):1503-1507. View abstract.

Ando, S., De Amicis, F., Rago, V., Carpino, A., Maggiolini, M., Panno, M. L., and Lanzino, M. Breast cancer: from estrogen to androgen receptor. Mol Cell Endocrinol. 7-31-2002;193(1-2):121-128. View abstract.

Ayotte, C., Levesque, J. F., Cle, roux M., Lajeunesse, A., Goudreault, D., and Fakirian, A. Sport nutritional supplements: quality and doping controls. Can J Appl Physiol 2001;26 Suppl:S120-S129. View abstract.

Battista, V., Combs, J., and Warme, W. J. Asynchronous bilateral achilles tendon ruptures and androstenediol use. Am J Sports Med 2003;31(6):1007-1009. View abstract.

Bird, C. E., Morrow, L., Fukumoto, Y., Marcellus, S., and Clark, A. F. Delta5-androstenediol: kinetics of metabolism and binding to plasma proteins in normal men and women. J Clin Endocrinol.Metab 1976;43(6):1317-1322. View abstract.

Blizzard, T. A., Gude, C., Morgan, J. D., Chan, W., Birzin, E. T., Mojena, M., Tudela, C., Chen, F., Knecht, K., Su, Q., Kraker, B., Mosley, R. T., Holmes, M. A., Sharma, N., Fitzgerald, P. M., Rohrer, S. P., and Hammond, M. L. Androstenediol analogs as ER-beta-selective SERMs. Bioorg.Med Chem Lett 2-15-2006;16(4):834-838. View abstract.

Broeder, C. E. Oral andro-related prohormone supplementation: do the potential risks outweigh the benefits? Can J Appl Physiol 2003;28(1):102-116. View abstract.

Brown, G. A. and McKenzie, D. Acute resistance exercise does not change the hormonal response to sublingual androstenediol intake. Eur J Appl Physiol 2006;97(4):404-412. View abstract.

Brown, G. A., Vukovich, M., and King, D. S. Testosterone prohormone supplements. Med Sci Sports Exerc 2006;38(8):1451-1461. View abstract.

Delbeke, F. T., Van Eenoo, P., Van Thuyne, W., and Desmet, N. Prohormones and sport. J Steroid Biochem Mol Biol 2002;83(1-5):245-251. View abstract.

Foster, Z. J. and Housner, J. A. Anabolic-androgenic steroids and testosterone precursors: ergogenic aids and sport. Curr.Sports Med Rep 2004;3(4):234-241. View abstract.

Hammer, F., Drescher, D. G., Schneider, S. B., Quinkler, M., Stewart, P. M., Allolio, B., and Arlt, W. Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging. J Clin Endocrinol.Metab 2005;90(11):6283-6289. View abstract.

Lardy, H., Marwah, A., and Marwah, P. C(19)-5-ene steroids in nature. Vitam.Horm. 2005;71:263-299. View abstract.

Leszczynski, D. E. and Schafer, R. M. Metabolic conversion of six steroid hormones by human plasma high-density lipoprotein. Biochim.Biophys.Acta 4-24-1991;1083(1):18-28. View abstract.

Leszczynski, D. E. and Schafer, R. M. Nonspecific and metabolic interactions between steroid hormones and human plasma lipoproteins. Lipids 1990;25(11):711-718. View abstract.

Loria, R. M. and Padgett, D. A. Androstenediol regulates systemic resistance against lethal infections in mice. Arch Virol. 1992;127(1-4):103-115. View abstract.

Loria, R. M. Immune up-regulation and tumor apoptosis by androstene steroids. Steroids 2002;67(12):953-966. View abstract.

Mitamura, K., Nagaoka, Y., Shimada, K., Honma, S., Namiki, M., Koh, E., and Mizokami, A. Simultaneous determination of androstenediol 3-sulfate and dehydroepiandrosterone sulfate in human serum using isotope diluted liquid chromatography-electrospray ionization-mass spectrometry. J Chromatogr.B Analyt.Technol.Biomed.Life Sci 10-25-2003;796(1):121-130. View abstract.

Pepin, G., Vayssette, F., and Gaillard, Y. [Urinary nandrolone metabolites in antidoping control]. Ann Pharm Fr 2001;59(5):345-349. View abstract.

Purohit, A., Woo, L. W., Chander, S. K., Newman, S. P., Ireson, C., Ho, Y., Grasso, A., Leese, M. P., Potter, B. V., and Reed, M. J. Steroid sulphatase inhibitors for breast cancer therapy. J Steroid Biochem Mol Biol 2003;86(3-5):423-432. View abstract.

Quinkler, M., Bumke-Vogt, C., Meyer, B., Bahr, V., Oelkers, W., and Diederich, S. The human kidney is a progesterone-metabolizing and androgen-producing organ. J Clin Endocrinol.Metab 2003;88(6):2803-2809. View abstract.

Reed, M. J., Lai, L. C., Ghilchik, M. W., and James, V. H. The effects of androgens and cortisol on the in vivo metabolism of oestradiol. J Steroid Biochem 1988;30(1-6):489-492. View abstract.

Reed, M. J., Purohit, A., Woo, L. W., Newman, S. P., and Potter, B. V. Steroid sulfatase: molecular biology, regulation, and inhibition. Endocr.Rev 2005;26(2):171-202. View abstract.

Reilly, C. A. and Crouch, D. J. Analysis of the nutritional supplement 1AD, its metabolites, and related endogenous hormones in biological matrices using liquid chromatography-tandem mass spectrometry. J Anal.Toxicol 2004;28(1):1-10. View abstract.

Saudan, C., Baume, N., Robinson, N., Avois, L., Mangin, P., and Saugy, M. Testosterone and doping control. Br J Sports Med 2006;40 Suppl 1:i21-i24. View abstract.

Schmidt, M., Kreutz, M., Loffler, G., Scholmerich, J., and Straub, R. H. Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages. J Endocrinol. 2000;164(2):161-169. View abstract.

Shackleton, C. H., Roitman, E., Phillips, A., and Chang, T. Androstanediol and 5-androstenediol profiling for detecting exogenously administered dihydrotestosterone, epitestosterone, and dehydroepiandrosterone: potential use in gas chromatography isotope ratio mass spectrometry. Steroids 1997;62(10):665-673. View abstract.

Tagawa, N., Hidaka, Y., Takano, T., Shimaoka, Y., Kobayashi, Y., and Amino, N. Serum concentrations of androstenediol and androstenediol sulfate, and their relation to cytokine production during and after normal pregnancy. Steroids 2004;69(10):675-680. View abstract.

Wang, C., Alexander, G., Berman, N., Salehian, B., Davidson, T., McDonald, V., Steiner, B., Hull, L., Callegari, C., and Swerdloff, R. S. Testosterone replacement therapy improves mood in hypogonadal men--a clinical research center study. J Clin Endocrinol.Metab 1996;81(10):3578-3583. View abstract.

Ziegenfuss, T. N., Berardi, J. M., and Lowery, L. M. Effects of prohormone supplementation in humans: a review. Can J Appl Physiol 2002;27(6):628-646. View abstract.

Anabolic Steroid Act, Public Law No. 108-358, 2004.

Broeder CE, Quindry J, Brittingham K, et al. The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000;160:3093-104. View abstract.

Brown GA, Martini ER, Roberts BS, et al. Acute hormonal response to sublingual androstenediol intake in young men. J Appl Physiol 2002;92:142-6. View abstract.

Brown GA, Vukovich MD, Martini ER, et al. Endocrine and lipid responses to chronic androstenediol-herbal supplementation in 30 to 58 year old men. J Am Coll Nutr 2001;20:520-8. View abstract.

Green GA, Catlin DH, Starcevic B. Analysis of over-the-counter dietary supplements. Clin J Sport Med 2001;11:254-9.. View abstract.

Miyamoto H, Yeh S, Lardy H, et al. Delta5-androstenediol is a natural hormone with androgenic activity in human prostate cancer cells. Proc Natl Acad Sci USA 1998;95:11083-88. View abstract.

National Collegiate Athletic Association. NCAA Banned-Drug Classes 2005-2006. Available at: http://www1.ncaa.org/membership/ed_outreach/health-safety/drug_testing/banned_drug_classes.pdf.

CONTINUE SCROLLING FOR RELATED SLIDESHOW

Health Solutions From Our Sponsors