Other Name(s):

Brionia, Bryone, Bryone Blanche, Bryone Dioïque, Bryonia alba, Bryonia cretica, Bryonia dioca, Bryoniae Radix, Couleuvrée, Devil's Turnip, English Mandrake, Herbe de Feu, Ladies' Seal, Mandragore Grimpante, Navet du Diable, Rave de Serpent, Tamus, Tetterberry, Vigne Blanche, Vigne du Diable, White Bryony, Wild Hops, Wild Nep, Wild Vine, Wood Vine.


Bryonia is a plant. People use the root for medicine.

Despite serious safety concerns, bryonia is used as a laxative to relieve constipation and as an emetic. Emetics are medicines that are used to cause vomiting.

Bryonia is also used to treat stomach and intestinal diseases, lung diseases, arthritis, liver disease, and metabolic disorders; and to prevent infections. It is also used to increase urination to relieve fluid retention.

How does it work?

Bryonia root contains a resin that has a strong laxative effect. Resin is a gum-like material.

Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

  • Stomach or intestinal diseases.
  • Lung diseases.
  • Arthritis.
  • Liver disease.
  • Metabolic disorders.
  • Fluid retention.
  • Preventing infections.
  • Causing vomiting.
  • Other conditions.
More evidence is needed to rate the effectiveness of bryonia for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).


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Side Effects

Bryonia is LIKELY UNSAFE for anyone to use. At fairly low doses, it can cause many side effects including dizziness, vomiting, convulsions, colic, bloody diarrhea, abortion, nervous excitement, and kidney damage. Larger doses may cause fatal poisoning. Just touching fresh bryonia can cause skin irritation. Eating the berries can cause death.

Special Precautions & Warnings

Pregnancy and breast-feeding: Bryonia is UNSAFE for pregnant women when taken by mouth and LIKELY UNSAFE for breast-feeding women when taken by mouth. It can cause a miscarriage in addition to serious health consequences for the pregnant or breast-feeding woman.

Children: Bryonia is LIKELY UNSAFE for children when taken by mouth. Eating the berries can cause death.

Stomach and intestinal (gastrointestinal, GI) disorders: There are many reasons not to use bryonia. It can cause serious side effects and death. Additionally, it can irritate the stomach and intestines and can make GI problems worse.


The appropriate dose of bryonia depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for bryonia. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


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Abud, A. P., Cesar, B., Cavazzani, L. F., de Oliveira, C. C., Gabardo, J., and Buchi, Dde F. Activation of bone marrow cells treated with Canova in vitro. Cell Biol Int 2006;30(10):808-816. View abstract.

Akihisa, T., Kimura, Y., Koike, K., Kokke, W. C., Nikaido, T., and Tamura, T. Cycloartane triterpenoids from the aerial part of Bryonia dioica. Phytochemistry 11-20-1998;49(6):1757-1760. View abstract.

Biglino, G. [Constituents of the root of Bryonia dioica. II. Isolation of delta 7-stigmastenol]. Farmaco Sci 1959;14:673-678. View abstract.

Biglino, G. and Nano, G. M. [Partial synthesis of bryogenine. XII. Constituents of Bryonia dioica root]. Farmaco Sci 1965;20(8):566-569. View abstract.

Biglino, G. and Nano, G. M. Constituents of the roots of Bryonia dioica Jacq. Farmaco Sci 1967;22(2):140-151. View abstract.

Cattel, L., Balliano, G., Caputo, O., and Viola, F. Biosynthesis of cucurbitacins in Bryonia dioica seedlings. Planta Med 1981;41(4):328-336. View abstract.

de Oliveira, C. C., de Oliveira, S. M., Godoy, L. M., Gabardo, J., and Buchi, Dde F. Canova, a Brazilian medical formulation, alters oxidative metabolism of mice macrophages. J Infect. 2006;52(6):420-432. View abstract.

FOWDEN, L. A new asparagine derivative, N4-(2-hydroxy-ethyl)-L-asparagine, from bryony (Bryonia dioica). Biochem.J. 1961;81:154-156. View abstract.

Francisco, J. A., Gawlak, S. L., Miller, M., Bathe, J., Russell, D., Chace, D., Mixan, B., Zhao, L., Fell, H. P., and Siegall, C. B. Expression and characterization of bryodin 1 and a bryodin 1-based single-chain immunotoxin from tobacco cell culture. Bioconjug.Chem. 1997;8(5):708-713. View abstract.

Gawlak, S. L., Neubauer, M., Klei, H. E., Chang, C. Y., Einspahr, H. M., and Siegall, C. B. Molecular, biological, and preliminary structural analysis of recombinant bryodin 1, a ribosome-inactivating protein from the plant Bryonia dioica. Biochemistry 3-18-1997;36(11):3095-3103. View abstract.


Gupta, M., Mazumdar, U. K., Sivakumar, T., Vamsi, M. L., Karki, S. S., Sambathkumar, R., and Manikandan, L. Evaluation of anti-inflammatory activity of chloroform extract of Bryonia laciniosa in experimental animal models. Biol.Pharm.Bull. 2003;26(9):1342-1344. View abstract.

Karageuzyan, K. G., Vartanyan, G. S., Agadjanov, M. I., Panossian, A. G., and Hoult, J. R. Restoration of the disordered glucose-fatty acid cycle in alloxan-diabetic rats by trihydroxyoctadecadienoic acids from Bryonia alba, a native Armenian medicinal plant. Planta Med. 1998;64(5):417-422. View abstract.

Karagezian, K. G., Vartanian, G. S., and Panosian, A. G. [Effect of an extract from the roots of bryony (Bryonia alba) on lipid peroxidation in the liver of rats with alloxan diabetes]. Biull.Eksp.Biol.Med. 1981;92(8):35-37. View abstract.

Khan, M. T., Choudhary, M. I., Atta, ur Rahman, Mamedova, R. P., Agzamova, M. A., Sultankhodzhaev, M. N., and Isaev, M. I. Tyrosinase inhibition studies of cycloartane and cucurbitane glycosides and their structure-activity relationships. Bioorg.Med Chem 9-1-2006;14(17):6085-6088. View abstract.

Konopa, J., Jereczek-Morawska, E., Matuszkiewicz, A., and Nazarewicz, T. Antitumor substances from Bryonia alba L. Neoplasma 1966;13(3):335-338. View abstract.

Konopa, J., Matuszkiewicz, A., Hrabowska, M., and Onoszka, K. Cucurbitacines, cytotoxic and antitumor substances from Bryonia alba L. Part II: Biological studies. Arzneimittelforschung. 1974;24(11):1741-1743. View abstract.

Konopa, J., Zielinski, J., and Matuszkiewicz, A. Cucurbitacins, cytotoxic and antitumor substances from Bryonia alba L. I: isolation and identification. Arzneimittelforschung. 1974;24(10):1554-1557. View abstract.

LARSEN, K. [Medicinal and poisonous plants. VIII. Bryonia alba and Bryonia dioica.]. Nord.Med. 5-24-1962;67:675. View abstract.

Mahasneh, A. M. and El Oqlah, A. A. Antimicrobial activity of extracts of herbal plants used in the traditional medicine of Jordan. J.Ethnopharmacol. 1999;64(3):271-276. View abstract.

Merck, C. C., Sonnenwald, B., and Rollwage, H. [The administration of homeopathic drugs for the treatment of acute mastitis in cattle]. Berl Munch.Tierarztl.Wochenschr. 8-1-1989;102(8):266-272. View abstract.

Munoz, S. M., Salvarelli, S. M., Saiz, M. I., and Conde, F. P. A toxic protein from Bryonia dioica Jacq. fruits: the brydiofin. Biochem Biophys Res Commun 3-31-1992;183(3):1011-1018. View abstract.

Nersesyan, A. K. and Collins, A. R. Possible genotoxic activity of extracts of Bryonia alba roots on human lymphocytes and transformed cells. Neoplasma 2002;49(2):114-116. View abstract.

Oobayashi, K., Yoshikawa, K., and Arihara, S. Structural revision of bryonoside and structure elucidation of minor saponins from Bryonia dioica. Phytochemistry 1992;31(3):943-946. View abstract.

Otlewski, J., Whatley, H., Polanowski, A., and Wilusz, T. Amino-acid sequences of trypsin inhibitors from watermelon (Citrullus vulgaris) and red bryony (Bryonia dioica) seeds. Biol Chem Hoppe Seyler 1987;368(11):1505-1507. View abstract.

Panosian, A. G. [Effect of Bryonia cucurbitacins on the biosynthesis of eicosanoids in human leukocytes]. Bioorg.Khim. 1985;11(2):264-269. View abstract.

Panosian, A. G., Avetisian, G. M., Karagezian, K. G., Vartanian, G. S., and Buniatian, G. K. [Hypoglycemic action of Bryonia alba L. unsaturated fatty trihydroxy acids in alloxan diabetes]. Dokl.Akad.Nauk SSSR 1981;256(5):1267-1269. View abstract.

Panosian, A. G., Dadaian, M. A., and Gabrielian, E. S. [Cucurbitacin R glycoside--a regulator of steroidogenesis and of the formation of prostaglandin E2--a specific modulator of the hypothalamus-hypophysis-adrenal cortex system]. Biull.Eksp.Biol.Med. 1987;104(10):456-457. View abstract.

Panossian, A. G., Avetissian, G. M., Mnatsakanian, V. A., Batrakov, S. G., Vartanian, S. A., Gabrielian, E. S., and Amroyan, E. A. Unsaturated polyhydroxy acids having prostaglandin-like activity from Bryonia alba II. Major components. Planta Med. 1983;47(1):17-25. View abstract.

Panossian, A. G., Oganessian, A. S., Ambartsumian, M., Gabrielian, E. S., Wagner, H., and Wikman, G. Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva. Phytomedicine. 1999;6(1):17-26. View abstract.

Panossian, A., Gabrielian, E., and Wagner, H. On the mechanism of action of plant adaptogens with particular reference to cucurbitacin R diglucoside. Phytomedicine. 1999;6(3):147-155. View abstract.

Paris, R. R., Delaveau, P. G., and Leiba, S. [On the presence of C-heterosides in bryony (Bryonia dioica Jacq.). Isolation of a C-flavonoside identified as alliaroside]. C.R.Acad Sci Hebd.Seances Acad Sci D. 3-21-1966;262(12):1372-1374. View abstract.

Polanowski, A., Cieslar, E., Otlewski, J., Nienartowicz, B., Wilimowska-Pelc, A., and Wilusz, T. Protein inhibitors of trypsin from the seeds of Cucurbitaceae plants. Acta Biochim.Pol. 1987;34(4):395-406. View abstract.

Seligmann, I. C., Lima, P. D., Cardoso, P. C., Khayat, A. S., Bahia, M. O., Buchi, Dde F., Cabral, I. R., and Burbano, R. R. The anticancer homeopathic composite "Canova Method" is not genotoxic for human lymphocytes in vitro. Genet.Mol.Res. 6-30-2003;2(2):223-228. View abstract.

Siegall, C. B., Gawlak, S. L., Chace, D., Wolff, E. A., Mixan, B., and Marquardt, H. Characterization of ribosome-inactivating proteins isolated from Bryonia dioica and their utility as carcinoma-reactive immunoconjugates. Bioconjug.Chem. 1994;5(5):423-429. View abstract.

Sivakumar, T., Perumal, P., Kumar, R. S., Vamsi, M. L., Gomathi, P., Mazumder, U. K., and Gupta, M. Evaluation of analgesic, antipyretic activity and toxicity study of Bryonia laciniosa in mice and rats. Am.J.Chin Med. 2004;32(4):531-539. View abstract.

Suganda, A. G., Amoros, M., Girre, L., and Fauconnier, B. [Inhibitory effects of some crude and semi-purified extracts of indigenous French plants on the multiplication of human herpesvirus 1 and poliovirus 2 in cell culture]. J Nat Prod 1983;46(5):626-632. View abstract.

Tunmann, P. [ON BRYOAMARIDE FROM THE ROOT OF BRYONIA DIOICA JACQ]. Arzneimittelforschung 1964;14:1366-1367. View abstract.

Tunmann, P. and LINDE, H. [Contribution to the knowledge on the nitrogen-containing constituents in Bryonia dioica root]. Arch Pharm Ber.Dtsch.Pharm Ges. 1958;291/63(5):263-268. View abstract.

Tunmann, P. and SCHEHRER, F. K. [Contribution to the chemical composition of bryodulcosides. Part 3. On the constituents of the roots of Bryonia dioeca Jacqu]. Arch Pharm 1959;292/64:745-748. View abstract.

Tunmann, P. and Stapel, G. [On bryodulcoside. 8. On substances found in the root of Bryonia dioica Jacq]. Arch Pharm Ber.Dtsch.Pharm Ges. 1966;229(7):596-598. View abstract.

Tunmann, P. and WIENECKE, H. [On the first crystalline bitter glycoside from the Cucurbitaceae. Isolation and properties of brvoamaride. 4. Report on the ingredients in the roots of Bryonia dioeca Jaqu]. Arch Pharm 1960;293/65:195-202. View abstract.

Tunmann, P. and WOLF, G. [Glycosides of Bryonia dioeca root]. Arch Pharm Ber.Dtsch.Pharm Ges. 1956;289/61(9-10):459-469. View abstract.

Ukiya, M., Akihisa, T., Yasukawa, K., Tokuda, H., Toriumi, M., Koike, K., Kimura, Y., Nikaido, T., Aoi, W., Nishino, H., and Takido, M. Anti-inflammatory and anti-tumor-promoting effects of cucurbitane glycosides from the roots of Bryonia dioica. J.Nat.Prod. 2002;65(2):179-183. View abstract.

Varshney, J. P. and Naresh, R. Comparative efficacy of homeopathic and allopathic systems of medicine in the management of clinical mastitis of Indian dairy cows. Homeopathy 2005;94(2):81-85. View abstract.

Varshney, J. P. and Naresh, R. Evaluation of a homeopathic complex in the clinical management of udder diseases of riverine buffaloes. Homeopathy 2004;93(1):17-20. View abstract.

Vartanian, G. S. and Karagezian, K. G. [Normalizing effect of Bryonia alba L. on blood phospholipids in alloxan diabetes]. Vopr.Med.Khim. 1981;27(2):179-181. View abstract.

Vartanian, G. S., Agadzhanov, M. I., and Karagezian, K. G. [Regulating effect of trihydroxyoctadecadienoic acids from Bryonia alba on glucose-fatty acids cycle in alloxan diabetes]. Dokl.Akad.Nauk 1998;361(5):692-694. View abstract.

Vartanian, G. S., Parsadanian, G. K., and Karagezian, K. G. [Effect of trihydroxyoctadecadiene acids from Bryonia alba L. on the activity of glycogen metabolism enzymes in alloxan diabetes]. Biull.Eksp.Biol.Med. 1984;97(3):295-297. View abstract.

Wachinger, M., Samtleben, R., Gerhauser, C., Wagner, H., and Erfle, V. Bryodin, a single-chain ribosome-inactivating protein, selectively inhibits the growth of HIV-1-infected cells and reduces HIV-1 production. Res.Exp.Med.(Berl) 1993;193(1):1-12. View abstract.

Whur, P. White bryony poisoning in a dog. Vet.Rec. 10-18-1986;119(16):411. View abstract.

Paris, A., Gonnet, N., Chaussard, C., Belon, P., Rocourt, F., Saragaglia, D., and Cracowski, J. L. Effect of homeopathy on analgesic intake following knee ligament reconstruction: a phase III monocentre randomized placebo controlled study. Br J Clin Pharmacol 2008;65(2):180-187. View abstract.

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