Caffeic Acid

Other Name(s):

3,4-DA, 3,4-Dihydroxycinnamic acid, 3,4-Dihydroxycinnamic Acid, 2-Propenoic Acid, 3-(3,4-dihydroxyphenyl), 3-(3,4-Dihydroxy Phenyl)-2-Propenoic Acid, 3-(3,4-Dihydroxyphenyl)Propenoic Acid, 3,4-Dihydroxybenzeneacrylic Acid, 4-(2-Carboxyethenyl)-1,2-Dihydroxybenzene, 4-(2'-Carboxyvinyl)-1,2-Dihydroxybenzene, (2E)-3-(3,4-Dihydroxyphenyl)-2-Propenoic Acid, Acide Caféique, Ácido Cafeico.

Overview

Caffeic acid is a chemical found in many plants and foods. Coffee is the primary source of caffeic acid in the human diet. However, it can be found in other food sources such as apples, artichoke, berries, and pears. Wine also contains a significant amount of caffeic acid.

Caffeic acid is used in supplements for boosting athletic performance, exercise-related fatigue, weight loss, cancer, HIV/AIDS, herpes, and other conditions.

How does it work?

Caffeic acid is thought to have many effects in the body including antioxidant and anti-inflammatory effects. It might also affect the immune system in the body. Test tube studies show that it might decrease the growth of cancer cells and viruses. Animal studies show that it might have a mild stimulant effect and reduce fatigue related to exercise. The effects of caffeic acid when taken by people are not known.

Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

More evidence is needed to rate caffeic acid for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

QUESTION

Next to red peppers, you can get the most vitamin C from ________________. See Answer

Side Effects

There is not enough information to know if caffeic acid is safe when taken as a supplement. Caffeic acid is contained in many foods we eat, however, taking purified caffeic acid as a supplement has not been studied in people.

Special Precautions & Warnings

Pregnancy and breast-feeding: There is not enough information to know if caffeic acid when taken as a supplement is safe during pregnancy and breast feeding. It should be avoided.

Insomnia. Caffeic acid might have a mild stimulating effect that could possibly worsen insomnia. However, this effect is modest and substantially less than caffeine.

Interactions


Medications moved by pumps in cells (Organic Anion Transporter 1 (OAT1) Substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are moved by pumps in cells. Caffeic acid might change how these pumps work and increase how much medication stays in the body. In some cases this might result in an increased chance of having medication side effects.

Some of these medications include acyclovir (Zovirax), adefovir (Hepsera), cephalosporins, cidofovir (Vistide), cimetidine (Tagamet), ciprofloxacin (Cipro), furosemide (Lasix), hydrochlorothiazide (HCTZ), NSAIDs, oseltamivir (Tamiflu), pravastatin (Pravachol), probenecid, simvastatin (Zocor), and zidovudine (Retrovir).


Medications moved by pumps in cells (Organic Anion Transporter 3 (OAT3) Substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are moved by pumps in cells. Caffeic acid might change how these pumps work and increase how much medication stays in the body. In some cases this might result in an increased chance of having medication side effects.

Some of these medications include cephalosporins, famotidine (Pepcid), furosemide (Lasix), hydrochlorothiazide (HCTZ), methotrexate, NSAIDs, probenecid, and ranitidine (Zantac).


LevodopaInteraction Rating: Minor Be cautious with this combination.Talk with your health provider.

Caffeic acid might change the way the body breaks down and gets rid of levodopa. However, it's not known how important this possible interaction might be.

SLIDESHOW

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Dosing

The appropriate dose of caffeic acid depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for caffeic acid. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Reviewed on 6/14/2021
References

Chang WC, Hsieh CH, Hsiao MW, et al. Caffeic acid induces apoptosis in human cervical cancer cells through the mitochondrial pathway. Taiwan J Obstet Gynecol 2010;49:419-24. View abstract.

Chung TW, Moon SK, Chang YC, et al. Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism. FASEB J 2004;18:1670-81. View abstract.

Dayman J, Jepson JB. The metabolism of caffeic acid in humans: the dehydroxylating action of intestinal bacteria. Biochem J 1969;113(2):11P. View abstract.

Farah A, Donangelo CM. Phenolic compounds in coffee. Braz J Plant Physiol 2006;18:23-36.

Ferreira PG, Lima MA, Bernedo-Navarro RA, et al. Stimulation of acidic reduction of nitrite to nitric oxide by soybean phenolics: possible relevance to gastrointestinal host defense. J Agric Food Chem 2011;59:5609-19. View abstract.

Ikeda K, Tsujimoto K, Uozaki M, et al. Inhibition of multiplication of herpes simplex virus by caffeic acid. Int J Mol Med 2011;28:595-8. View abstract.

Kim JH, Lee BJ, Kim JH, et al. Antiangiogenic effect of caffeic acid on retinal neovascularization. Vascul Pharmacol 2009;51:262-7. View abstract.

Nardini M, D'Aquino M, Tomassi G, et al. Inhibition of human low-density lipoprotein oxidation by caffeic acid and other hydroxycinnamic acid derivatives. Free Radic Biol Med 1995;19:541-52. View abstract.

Novaes RD, Gonçalves RV, Peluzio Mdo C, et al. 3,4-Dihydroxycinnamic acid attenuates the fatigue and improves exercise tolerance in rats. Biosci Biotechnol Biochem 2012;76:1025-7. View abstract.

Ohnishi R, Ito H, Iguchi A, et al. Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice. Biosci Biotechnol Biochem 2006;70:2560-3. View abstract.

Olthol MR, Hollman PCH, Katan MB. Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr 2001;131:66-71. View abstract.

Renouf M, Guy PA, Marmet C, et al. Measurement of caffeic and ferulic acid equivalents in plasma after coffee consumption: small intestine and colon are key sites for coffee metabolism. Mol Nutr Food Res 2010;54:760-6. View abstract.

Shinomiya K, Omichi J, Ohnishi R, et al. Effects of chlorogenic acid and its metabolites on the sleep-wakefulness cycle in rats. Eur J Pharmacol 2004;504:185-9. View abstract.

Simonetti P, Gardana C, Pietta P. Plasma levels of caffeic acid and antioxidant status after red wine intake. J Agric Food Chem 2001;49:5964-8. View abstract.

Uwai Y, Ozeki Y, Isaka T, et al. Inhibitory effect of caffeic acid on human organic anion transporters hOAT1 and hOAT3: a novel candidate for food-drug interaction. Drug Metab Pharmacokinet 2011;26:486-93. View abstract.

Wallerath T, Li H, Godtel-Ambrust U, et al. A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase. Nitric Oxide 2005;12:97-104. View abstract.

Wang LH, Hsu KY, Uang YS, et al. Caffeic acid improves the bioavailability of L-dopa in rabbit plasma. Phytother Res 2010;24:852-8. View abstract.

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