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Can Leukemia Be Cured?

Reviewed on 1/12/2021

What Is Leukemia?

Leukemia is a cancer of the blood cells, usually the white blood cells though it can start in other types of blood cells. In patients with leukemia, the bone marrow in the center of the bones produces abnormal blood cells that grow out of control and get into the bloodstream. 

There are several types of leukemia, including:    

Some types of leukemia grow slowly ("chronic leukemias"), and others grow faster ("acute leukemias"). Patients may have a chronic leukemia at first and that later develops into a fast-growing acute leukemia.

What Are Symptoms of Leukemia?

Leukemia may not cause symptoms, especially at first. When symptoms of leukemia occur, they may include:

  • Tiredness/fatigue
  • Weakness
  • Bleeding more easily than normal
  • Getting sick from infections more easily than normal
  • Dizziness or lightheadedness
  • Shortness of breath
  • Pale skin
  • Bruises (or small red or purple spots) on the skin
  • Bleeding, such as frequent or severe nosebleeds, bleeding gums, or heavy menstrual bleeding in women
  • Clotting problems
  • Swelling in the abdomen
  • Enlarged lymph nodes
  • Bone or joint pain
  • Feeling cold
  • Headaches

Patients with leukemia may also have generalized symptoms such as:

What Causes Leukemia?

Acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML) are caused by genetic mutations. 

Some cases of chronic myelomonocytic leukemia (CMML) are linked to cancer treatment, but in most cases the cause is unknown.

Risk factors for developing acute lymphocytic leukemia (ALL) include:

  • Radiation exposure
  • Chemical exposure such as chemotherapy drugs and other chemicals, including benzene
  • Viral infections such as human T-cell lymphoma/leukemia virus-1 (HTLV-1) (not common in the U.S.), Epstein-Barr virus (EBV) 
  • Certain genetic conditions
  • Age over 50
  • Race/ethnicity – more common in Caucasians
  • Gender – slightly more common in females
  • Having an identical twin with ALL 
  • Possible other risk factors
    • Exposure to electromagnetic fields (such as living near power lines or using cell phones)
    • Workplace exposure to diesel, gasoline, pesticides, and certain other chemicals
    • Smoking
    • Exposure to hair dyes

Risk factors for developing acute myeloid leukemia (AML) include:

  • Getting older
  • Being male
  • Smoking
  • Exposure to certain chemicals, such as long-term exposure to benzene 
  • Certain chemotherapy drugs including alkylating agents and topoisomerase II inhibitors 
  • Exposure to radiation
  • Having certain blood disorders including chronic myeloproliferative disorders such as polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis
  • Certain genetic syndromes
  • A family history
  • Possible other risk factors 
    • Exposure to electromagnetic fields (such as living near power lines)
    • Workplace exposure to diesel, gasoline, and certain other chemicals and solvents
    • Exposure to herbicides or pesticides

Risk factors for developing chronic lymphocytic leukemia (CLL) include:

  • Age over 50 
  • Exposure to certain chemicals, such as Agent Orange, radon, and possible certain pesticides
  • Family history
  • Gender – slightly more common in males
  • Race/ethnicity - more common in North America and Europe than in Asia.

Risk factors for developing chronic myeloid leukemia (CML) include:

  • Exposure to high-dose radiation (such as being a survivor of an atomic bomb blast or nuclear reactor accident) 
  • Getting older
  • Gender: slightly more common in males

Risk factors for developing chronic myelomonocytic leukemia (CMML) include:

  • Age: CMML is rare in people under age 40. Most cases occur in people 60 and older.
  • Gender: Twice as common in men as in women
  • Prior cancer treatment with chemotherapy 

QUESTION

What is leukemia? See Answer

How Is Leukemia Diagnosed?

Leukemia is diagnosed with tests such as:

What Is the Treatment for Leukemia?

There is technically no cure for leukemia, but treatment can help the cancer go into remission (also called “no evidence of disease”). It is not always possible to tell if any cancer cells remain in the body, which is why doctors often refer to “no evidence of disease” as remission rather than a cure. Whether or not remission occurs depends on the type of leukemia and the stage of the cancer. 

Treatment for leukemia can include one or more of the following:

  • Chemotherapy 
  • Immunotherapy 
  • Targeted therapy
  • Bone marrow transplant (also called "stem cell transplant") 
  • Radiation
  • Surgery

What Are Complications of Leukemia?

Complications of leukemia may include:

  • Infection
  • Anemia
  • Compromised immune system
  • Developing a second cancer
  • Death

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Reviewed on 1/12/2021
References
https://www.uptodate.com/contents/leukemia-in-adults-the-basics

https://www.cancer.org/cancer/leukemia.html

https://www.lls.org/leukemia?src1=27336&src2=

https://www.cancer.net/navigating-cancer-care/cancer-basics/cancer-terms
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