Birch Mushroom, Chaga Conk, Champignon de l’Immortalité, Cinder Conk, Clinker Polypore, Diamant de la Forêt, Don de Dieu, Inonotus obliquus, Roi des Plantes, Siberian Chaga, Tchaga.
Chaga is a fungus. It produces a woody growth, called a conk, which is used to make medicine.
People take chaga by mouth for heart disease, diabetes, stomach and intestine cancer, liver disease, parasites, stomach pain, and tuberculosis.
How does it work?
Chaga might stimulate the immune system. It contains some chemicals that have antioxidant effects. Chaga might lower blood sugar and cholesterol levels.
Insufficient Evidence to Rate Effectiveness for...
- Heart disease.
- Stomach and intestinal cancer.
- Liver disease.
- Other conditions.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
"Auto-immune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or other conditions: Chaga might cause the immune system to become more active. This could increase the symptoms of auto-immune diseases. If you have one of these conditions, it's best to avoid using chaga.
Bleeding disorders: There is concern that chaga might increase the risk of bleeding. Don't use chaga if you have a bleeding disorder.
Diabetes: Chaga might lower blood sugar levels in people with diabetes. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use chaga products. The dose of your diabetes medications may need to be adjusted by your healthcare provider.
Surgery: Chaga might affect blood sugar control or increase the risk of bleeding during and after surgery. Stop using chaga at least 2 weeks before a scheduled surgery.
Medications for diabetes (Antidiabetes drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Chaga might lower blood sugar. Diabetes medications are also used to lower blood sugar. Taking chaga along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Medications that decrease the immune system (Immunosuppressants)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Chaga might make the immune system more active. Some medications decrease the immune system. Taking chaga along with medications that decrease the immune system might decrease the effectiveness of these medications.
Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Chaga might slow blood clotting. Taking chaga along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
The appropriate dose of chaga depends on several factors such is the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for chaga. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
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Babitskaia VG, Shcherba VV, Ikonnikova NV. [Melanin complex of the fungus Inonotus obliquus]. Prikl Biokhim Mikrobiol 2000;36(4):439-44. View abstract.
Babitskaia VG, Shcherba VV. [The nature of melanin pigments from some micro- and macromycetes]. Prikl Biokhim Mikrobiol 2002;38(3):286-91. View abstract.
Burczyk J, Gawron A, Slotwinska M, et al. Antimitotic activity of aqueous extracts of Inonotus obliquus. Boll Chim Farm 1996;135(5):306-9. View abstract.
Chen CF, Xiang XY, Gu Q, et al. Submerged fermentation conditions for synthesis of extracellular polysaccharide by Inonotus obliquus. Chinese Traditional and Herbal Drugs (China) 2007;38:358-61.
Cui Y, Kim DS, Park KC. Antioxidant effect of Inonotus obliquus. J Ethnopharmacol 2005;96(1-2):79-85. View abstract.
Ham SS, Kim SH, Moon SY, et al. Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract. Mutat Res 2009;672(1):55-9. View abstract.
Hyun KW, Jeong SC, Lee DH, et al. Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus. Peptides 2006;27(6):1173-8. View abstract.
Jarosz A, Skorska M, Rzymowska J, et al. Effect of the extracts from fungus Inonotus obliquus on catalase level in HeLa and nocardia cells. Acta Biochim Pol 1990;37(1):149-51. View abstract.
Kahlos K, Hellen L, Nummila H, Hiltunen R. Experiments on cultures of Inonotus obliquus. Planta Med 1986;52(6):507-8. View abstract.
Kahlos K, Hiltunen R, V Schantz M. 3beta-Hydroxy-lanosta-8,24-dien-21-al, a new triterpene from Inontus obliquus. Planta Med 1984;50(2):197-8. View abstract.
Kahlos K, Hiltunen R. 3beta, 22-Dihydroxylanosta-7,9(11), 24-triene: a new, minor compound from Inonotus obliquus. Planta Med 1986;52(6):495-6. View abstract.
Kahlos K, Hiltunen R. Gas chromatographic-mass spectrometric identification of some lanostanes from Inonotus obliquus. Acta Pharm Fenn 1988;97:45-9.
Kahlos K, Hiltunen R. Two new oxygenated lanostane type triterpenes from Inonotus obliquus. Pharm Fenn 1986;95:71-6.
Kahlos K, Kangas L, Hiltunen R. Antitumor activity of some compounds and fractions from an n-hexane extract of Inonotus obliquus. Acta Pharm Fenn 1987;96:33-40.
Kahlos K, Kangas L, Hiltunen R. Antitumor activity of triterpenes in Inonotus obliquus. Planta Med 1986;52(6):554. View abstract.
Kahlos K, Kangas L, Hiltunen R. Antitumor tests of inotodiol from the fungus Inonotus obliquus. Acta Pharm Fenn 1986;95:173-7.
Kahlos K, Kangas L, Hiltunen R. Preliminary studies on the antitumor activity of polar fractions extracted from Inonotus obliquus. Acta Pharm Fenn 1987;96:167-74.
Kahlos K. Studies on triterpenes in Inonotus obliquus. Acta Pharm Fenn 1988;97:73.
Kim HG, Yoon DH, Kim CH, et al. Ethanol extract of Inonotus obliquus inhibits lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells. J Med Food 2007;10(1):80-9. View abstract.
Kim YO, Han SB, Lee HW, et al. Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus. Life Sci 2005;77(19):2438-56. View abstract.
Kim YO, Park HW, Kim JH, et al. Anti-cancer effect and structural characterization of endo-polysaccharide from cultivated mycelia of Inonotus obliquus. Life Sci 2006;79(1):72-80. View abstract.
Kukulianskaia TA, Kurchenko NV, Kurchenko VP, Babitskaia VG. [Physicochemical properties of melanins produced by Inonotus obliquus("chagi") in the nature and the cultivated fungus]. Prikl Biokhim Mikrobiol 2002;38(1):68-72. View abstract.
Lee IK, Kim YS, Jang YW, et al. New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus. Bioorg Med Chem Lett 2007;17(24):6678-81. View abstract.
Ma L, Chen H, Zhu W, Wang Z. Effect of different drying methods on physicochemical properties and antioxidant activities of polysaccharides extracted from mushroom Inonotus obliquus. Food Res Int 2013;50:633-640.
Mazurkiewicz W. Analysis of aqueous extract of Inonotus obliquus. Acta Pol Pharm 2006;63(6):497-501. View abstract.
Najafzadeh M, Reynolds PD, Baumgartner A, et al. Chaga mushroom extract inhibits oxidative DNA damage in lymphocytes of patients with inflammatory bowel disease. Biofactors 2007;31(3-4):191-200. View abstract.
Nakajima Y, Sato Y, Konishi T. Antioxidant small phenolic ingredients in Inonotus obliquus (persoon) Pilat (Chaga). Chem Pharm Bull (Tokyo) 2007;55(8):1222-6. View abstract.
Nakamura S, Iwami J, Asao Y, et al. New bioactive triterpene constituents from Inonotus obliquus. Journal of the Pharmaceutical Society of Japan 2007;127:58-60.
Nakata T, Yamada T, Taji S, et al. Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus. Bioorg Med Chem 2007;15(1):257-64. View abstract.
Nizkovskaia OP, Shivrina AN, Loviagina EV, et al. [Conditions for the formation of a pigment complex in Inonotus obliquus in artificial culture]. Mikrobiologiia 1960;29:441-5. View abstract.
Park JR, Park JS, Jo EH, et al. Reversal of the TPA-induced inhibition of gap junctional intercellular communication by Chaga mushroom (Inonotus obliquus) extracts: effects on MAP kinases. Biofactors 2006;27(1-4):147-55. View abstract.
Park YK, Lee HB, Jeon EJ, et al. Chaga mushroom extract inhibits oxidative DNA damage in human lymphocytes as assessed by comet assay. Biofactors 2004;21(1-4):109-12. View abstract.
Park YM, Won JH, Kim YH, et al. In vivo and in vitro anti-inflammatory and anti-nociceptive effects of the methanol extract of Inonotus obliquus. J Ethnopharmacol 2005;101(1-3):120-8. View abstract.
Rasina LN. [Effect of cryosubstance Chagi on deposition or isolation of 90Sr and on the effect of prolonged external exposure to gamma-radiation]. Radiats Biol Radioecol 2002;42(4):399-403. View abstract.
Rzymowska J. The effect of aqueous extracts from Inonotus obliquus on the mitotic index and enzyme activities. Boll Chim Farm 1998;137(1):13-5. View abstract.
Saar M. Fungi in Khanty folk medicine. J Ethnopharmacol 1991;31(2):175-9. View abstract.
Shivrina AN, Loviagina EV, Platonova EG. [Nature and origin of water-soluble pigment complex formed by Inonotus obliquus]. Biokhimiia 1959;24(1):67-72. View abstract.
Song Y, Hui J, Kou W, et al. Identification of Inonotus obliquus and analysis of antioxidation and antitumor activities of polysaccharides. Curr Microbiol 2008;57(5):454-62. View abstract.
Sun JE, Ao ZH, Lu ZM, et al. Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice. J Ethnopharmacol 2008;118(1):7-13. View abstract.
Sung B, Pandey MK, Nakajima Y, et al. Identification of a novel blocker of IkappaBalpha kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-kappaB. Mol Cancer Ther 2008;7(1):191-201. View abstract.
Taji S, Yamada T, Wada S, et al. Lanostane-type triterpenoids from the sclerotia of Inonotus obliquus possessing anti-tumor promoting activity. Eur J Med Chem 2008;43(11):2373-9. View abstract.
Youn MJ, Kim JK, Park SY, et al. Chaga mushroom (Inonotus obliquus) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells. World J Gastroenterol 2008;14(4):511-7. View abstract.
Yudoh K, Matsui H, Tsuji H. Nitric oxide induced by tumor cells activates tumor cell adhesion to endothelial cells and permeability of the endothelium in vitro. Clin Exp Metastasis 1997;15(6):557-67. View abstract.
Zheng W, Zhang M, Zhao Y, et al. Accumulation of antioxidant phenolic constituents in submerged cultures of Inonotus obliquus. Bioresour Technol 2009;100(3):1327-35. View abstract.
Zheng WF, Liu T, Xiang XY, Gu Q. Sterol composition in field-grown and cultured mycelia of Inonotus obliquus. Yao Xue Xue Bao 2007;42(7):750-6. View abstract.