Symptoms and Signs of Childhood Hodgkin Lymphoma

Medical Author:
Medically Reviewed on 9/17/2021

Doctor's Notes on Childhood Hodgkin Lymphoma

Childhood Hodgkin lymphoma is a type of cancer that occurs when cells in the lymph system, part of the body's immune system, start to grow abnormally. The two types of childhood Hodgkin lymphoma are:

  1. classical Hodgkin lymphoma and
  2. nodular lymphocyte-predominant Hodgkin lymphoma.

Classical Hodgkin lymphoma is further divided into four subtypes, based on how the cancer cells look under a microscope:

  1. lymphocyte-rich classical Hodgkin lymphoma,
  2. nodular sclerosis Hodgkin lymphoma,
  3. mixed cellularity Hodgkin lymphoma, and
  4. lymphocyte-depleted Hodgkin lymphoma. 

Symptoms of childhood Hodgkin lymphoma include:

What Is the Treatment for Childhood Hodgkin Lymphoma?

The treatment for childhood Hodgkin lymphoma depends upon the extent of spread, or stage, of the disease as well as the type of Hodgkin lymphoma that is present:

  • Chemotherapy is a common treatment that is often combined with radiation therapy.
  • Hodgkin lymphoma that returns after therapy is often treated with chemotherapy followed by stem cell transplant.
  • Other drugs that may be used to treat Hodgkin lymphoma include targeted drugs that attack specific cancer cells and immunotherapy that works to activate the body’s immune system to kill the cancer cells. 


Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.