Other Name(s):

Ch'ih Shen, Chinese Red Sage, Chinese Salvia, Dan Shen, Dan-Shen, Huang Ken, Pin-Ma Ts'ao, Racine de Salvia, Radix Salviae Miltiorrhizae, Radix Salvie Miltiorrhiae, Red Rooted Sage, Red Sage, Sage Miltiorrhiza, Salvia bowelyana, Salvia miltiorrhiza, Salvia przewalskii, Salvia Przewalskii Mandarinorum, Salvia Root, Salvia yunnanensis, Salviae Miltiorrhizae, Sauge Rouge, Sauge Rouge Chinoise, Shu-Wei Ts'ao, Tan Seng, Tan-Shen, Tzu Tan-Ken.


Danshen is an herb. People use the root to make medicine.

Danshen is used for circulation problems, “brain attack” (stroke), chest pain (angina pectoris), and other diseases of the heart and blood vessels. It is also used for menstrual disorders, chronic liver disease, and trouble sleeping caused by complaints such as rapid heartbeat and tight chest. Some people use danshen for skin conditions including acne, psoriasis, and eczema. It is also used to relieve bruising and to aid in wound healing.

How does it work?

Danshen appears to thin the blood by preventing platelet and blood clotting. It also causes blood vessels to widen, and this can improve circulation.

Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

  • Chest pain (angina). Early research suggests that taking danshen by mouth for up to 6 months is as effective as isosorbide dinitrate for reducing chest pain in heart disease patients.
  • Bronchitis. Early research suggests that injecting danshen in addition to usual treatment reduces symptoms of chronic asthmatic bronchitis and improves lung function after 3-4 days. However, by day 10, adding danshen to conventional therapy does not seem to produce additional benefit.
  • High cholesterol. Early research suggests that adding danshen acupoint injections to lipid-lowering medications for 30 days decreases total cholesterol, low density lipoprotein (LDL or “bad”) cholesterol, and certain blood fats called triglycerides it people with high cholesterol. It also seems to help increase high-density lipoprotein (HDL or “good”) cholesterol.
  • A type of stroke caused by a blood clot (ischemic stroke). Early research shows that receiving danshen by mouth or injecting danshen intravenously (by IV) might improve brain function after an ischemic stroke.
  • Kidney transplant. Early research suggests that receiving an injection with danshen for 10 days along with usual treatment improves kidney function after a kidney transplant, but does not reduce the risk of a transplant rejection.
  • Blood circulation problems.
  • Menstrual problems.
  • Abdominal masses.
  • Sleeplessness (insomnia) .
  • Acne.
  • Skin conditions.
  • Bruising.
  • Chronic liver inflammation (hepatitis).
  • Wound healing.
  • Other conditions.
More evidence is needed to rate the effectiveness of danshen for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).


Next to red peppers, you can get the most vitamin C from ________________. See Answer

Side Effects

Danshen is POSSIBLY SAFE when taken by mouth by most people. It can cause some side effects, including itching, upset stomach, and reduced appetite.

There is some concern that it might also cause drowsiness, dizziness, and a blood condition called thrombocytopenia. But there isn't enough information to know for sure if danshen causes these side effects.

Special Precautions & Warnings

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking danshen if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders: There is a concern that danshen might increase the risk of bleeding. If you have a bleeding disorder, don't use it.

Low blood pressure: Danshen might lower blood pressure. In theory, taking danshen might make blood pressure become too low in people with low blood pressure.

Surgery: Danshen might slow blood clotting, so there is a concern that it might increase the risk of extra bleeding during and after surgery. Stop using danshen at least 2 weeks before a scheduled surgery.


Digoxin (Lanoxin)Interaction Rating: Major Do not take this combination.

Digoxin (Lanoxin) helps the heart beat more strongly. Danshen also seems to affect the heart. Taking danshen along with digoxin can increase the effects of digoxin and increase the risk of side effects. Do not take danshen if you are taking digoxin (Lanoxin) without talking to your healthcare professional.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)Interaction Rating: Major Do not take this combination.

Danshen might slow blood clotting. Taking danshen along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Warfarin (Coumadin)Interaction Rating: Major Do not take this combination.

Warfarin (Coumadin) is used to slow blood clotting. Danshen might increase how long warfarin (Coumadin) is in the body, and increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.

Medications changed by the intestine (Cytochrome P450 3A4 (CYP3A4) substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are changed and broken down by the liver. Danshen use might increase how quickly the body breaks down some medications. Taking danshen along with some medications that are broken down by the liver can decrease the effectiveness of some medications. Before taking danshen talk to your healthcare provider if you are taking any medications that are changed by the body.

Some medications changed by the liver include lovastatin (Mevacor), clarithromycin (Biaxin), cyclosporine (Neoral, Sandimmune), diltiazem (Cardizem), estrogens, indinavir (Crixivan), triazolam (Halcion), and others.

Medications for high blood pressure (Antihypertensive drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Danshen might lower blood pressure. Using danshen with drugs that lower blood pressure might cause blood pressure to drop too much.

Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.

Midazolam (Versed, others)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Midazolam (Versed) is changed and broken down by the body. Danshen might increase how quickly this medication is broken down by the body. Use danshen with caution and under the supervision of a healthcare provider if you are taking midazolam (Versed).


Vitamin D Deficiency: How Much Vitamin D Is Enough? See Slideshow


The appropriate dose of danshen depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for danshen. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Health Solutions From Our Sponsors

Reviewed on 6/14/2021

Anonymous. Danshen in ischemic stroke. Chin Med J (Engl.) 1977;3(4):224-226. View abstract.

Bao, H. Y., Yu, H. L., and Wang, L. [Study on effect of Salvia injection in treating primary nephrotic syndrome and on endothelin and serum interleukin-2 receptor in children]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2002;22(1):28-29. View abstract.

Bao, Y. X., Wong, C. K., Leung, S. F., Chan, A. T., Li, P. W., Wong, E. L., Leung, P. C., Fung, K. P., Yin, Y. B., and Lam, C. W. Clinical studies of immunomodulatory activities of Yunzhi-Danshen in patients with nasopharyngeal carcinoma. J Altern Complement Med 2006;12(8):771-776. View abstract.

Cai, D. G. Advances in the study of chemical constituents of Danshen. Zhongguo Zhongyao Zazhi 1991;16:376-377.

Cao, P., Feng, R., and Feng, Z. Observation of Compound Dan Shen injection and snake venom for cerebral infarction. Chinese Traditional Medicine of Guangxi 1994;17(4):3-4, 8.

Chan, K., Chui, S. H., Wong, D. Y., Ha, W. Y., Chan, C. L., and Wong, R. N. Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction. Life Sci 11-12-2004;75(26):3157-3171. View abstract.

Chang, H. M., Chui, K. Y., Tan, F. W., Yang, Y., Zhong, Z. P., Lee, C. M., Sham, H. L., and Wong, H. N. Structure-activity relationship of miltirone, an active central benzodiazepine receptor ligand isolated from Salvia miltiorrhiza Bunge (Danshen). J Med Chem 1991;34(5):1675-1692. View abstract.

Chang, P. N., Mao, J. C., Huang, S. H., Ning, L., Wang, Z. J., On, T., Duan, W., and Zhu, Y. Z. Analysis of cardioprotective effects using purified Salvia miltiorrhiza extract on isolated rat hearts. J Pharmacol Sci 2006;101(3):245-249. View abstract.

Colombo, G., Agabio, R., Lobina, C., Reali, R., Morazzoni, P., Bombardelli, E., and Gessa, G. L. Salvia miltiorrhiza extract inhibits alcohol absorption, preference, and discrimination in sP rats. Alcohol 1999;18(1):65-70. View abstract.

Colombo, G., Serra, S., Vacca, G., Orru, A., Maccioni, P., Morazzoni, P., Bombardelli, E., Riva, A., Gessa, G. L., and Carai, M. A. Identification of miltirone as active ingredient of Salvia miltiorrhiza responsible for the reducing effect of root extracts on alcohol intake in rats. Alcohol Clin Exp Res 2006;30(5):754-762. View abstract.

Don, M. J., Shen, C. C., Syu, W. J., Ding, Y. H., and Sun, C. M. Cytotoxic and aromatic constituents from Salvia miltiorrhiza. Phytochemistry 2006;67(5):497-503. View abstract.

Dong, Z. T. and Jiang, W. D. Effect of danshensu on isolated swine coronary artery perfusion preparation. YaoxueXuebao 1982;17:226-228.

Guo, Z. X., Jia, W., Gao, W. Y., Xu, Z. H., Zhao, L. B., and Xiao, P. G. Clinical investigation of composite Danshen Dripping Pill for the treatment of angina pectoris. Zhongguo Tianran Yaowu 2003;1:124-128.

Han, Y., Wang, Z. K., and Wang, Z. D. [Observation on therapeutic effect of compound salvia drop-pill in treating vasovagol syncope]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2004;24(5):452-454. View abstract.

Hao, H., Wang, G., Cui, N., Li, J., Xie, L., and Ding, Z. Pharmacokinetics, absorption and tissue distribution of tanshinone IIA solid dispersion. Planta Med 2006;72(14):1311-1317. View abstract.

Hsieh, T. C. and Wu, J. M. Differential control of growth, cell cycle progression, and gene expression in human estrogen receptor positive MCF-7 breast cancer cells by extracts derived from polysaccharopeptide I'm-Yunity and Danshen and their combination. Int J Oncol 2006;29(5):1215-1222. View abstract.

Hu, J. and Ren, L. [Experimental study of the effect of danshen on the viability of burned skin]. Zhongguo Xiu.Fu Chong.Jian.Wai Ke.Za Zhi. 1998;12(4):205-208. View abstract.

Hung, H. H., Chen, Y. L., Lin, S. J., Yang, S. P., Shih, C. C., Shiao, M. S., and Chang, C. H. A salvianolic acid B-rich fraction of Salvia miltiorrhiza induces neointimal cell apoptosis in rabbit angioplasty model. Histol.Histopathol. 2001;16(1):175-183. View abstract.

Jin, D. Z., Yin, L. L., Ji, X. Q., and Zhu, X. Z. Cryptotanshinone inhibits cyclooxygenase-2 enzyme activity but not its expression. Eur J Pharmacol 11-7-2006;549(1-3):166-172. View abstract.

Kang, B. Y., Chung, S. W., Kim, S. H., Ryu, S. Y., and Kim, T. S. Inhibition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from Salvia miltiorrhiza. Immunopharmacology 2000;49(3):355-361. View abstract.

Kim, H. H., Kim, J., Ji, H. Y., Kim, Y. C., Sohn, D. H., Lee, B. M., and Lee, H. S. Pharmacokinetics of lithospermic acid B isolated from Salvia miltiorrhiza in rats. J Toxicol Environ Health A 12-10-2005;68(23-24):2239-2247. View abstract.

Kong, D. Y. Chemical constituents of Salvia miltiorrhiza (Danshen). Zhongguo Yiyao Gongye Zazhi 1989;20:279-285.

Kuang, P. and Xiang, J. Effect of radix salviae miltiorrhizae on EAA and IAA during cerebral ischemia in gerbils: a microdialysis study. J Tradit Chin Med 1994;14(1):45-50. View abstract.

Kuang, P. G., Wu, W. P., Zhang, F. Y., Liu, J. X., and Pu, C. Q. The effect of radix Salviae miltiorrhizae on vasoactive intestinal peptide in cerebral ischemia: an animal experiment. J Tradit.Chin Med 1989;9(3):203-206. View abstract.

Kuang, P., Tao, Y., and Shi, J. Effect of radix Salviae miltiorrhizae on extracellular adenosine and evaluation of its protective efficacy in ischemic reperfusion rat--microdialysis, HPLC and histopathologic studies. J Tradit Chin Med 1997;17(2):140-147. View abstract.

Kuang, P., Tao, Y., and Tian, Y. Effect of radix Salviae miltiorrhizae on nitric oxide in cerebral ischemic-reperfusion injury. J Tradit Chin Med 1996;16(3):224-227. View abstract.

Kuang, P., Tao, Y., and Tian, Y. Radix Salviae miltiorrhizae treatment results in decreased lipid peroxidation in reperfusion injury. J Tradit Chin Med 1996;16(2):138-142. View abstract.

Kuang, P., Wu, W., and Zhu, K. Evidence for amelioration of cellular damage in ischemic rat brain by radix salviae miltiorrhizae treatment--immunocytochemistry and histopathology studies. J Tradit Chin Med 1993;13(1):38-41. View abstract.

Lee, C. M., Wong, H. N., Chui, K. Y., Choang, T. F., Hon, P. M., and Chang, H. M. Miltirone, a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia miltiorrhiza. Neurosci Lett 6-24-1991;127(2):237-241. View abstract.

Li CP, Yung KH, and Chiu KW. Hypotensive action of Salvia miltiorrhiza cell culture extract. American Journal of Chinese Medicine 1990;18(3-4):157-166.

Li, L. N. Water soluble active components of

Li, W., Li, J., Ashok, M., Wu, R., Chen, D., Yang, L., Yang, H., Tracey, K. J., Wang, P., Sama, A. E., and Wang, H. A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol 3-15-2007;178(6):3856-3864. View abstract.

Li, X., Yu, C., Cai, Y., Liu, G., Jia, J., and Wang, Y. Simultaneous determination of six phenolic constituents of danshen in human serum using liquid chromatography/tandem mass spectrometry. J Chromatogr.B Analyt.Technol.Biomed.Life Sci 6-5-2005;820(1):41-47. View abstract.

Liang, T. J., Zhang, C. Q., and Zhang, W. [Effect of tongxinluo capsule on plasma endothelin and calcitonin gene related peptide in patients with unstable angina pectoris]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2002;22(6):435-436. View abstract.

Lin, Y. H., Liu, A. H., Wu, H. L., Westenbroek, C., Song, Q. L., Yu, H. M., Ter Horst, G. J., and Li, X. J. Salvianolic acid B, an antioxidant from Salvia miltiorrhiza, prevents Abeta(25-35)-induced reduction in BPRP in PC12 cells. Biochem Biophys.Res Commun. 9-22-2006;348(2):593-599. View abstract.

Liu, A. H., Lin, Y. H., Yang, M., Sun, J. H., Guo, H., and Guo, D. A. High-performance liquid chromatographic determination of tanshinones in the roots of Salvia miltiorrhiza and related traditional chinese medicinal preparations. J Pharm Pharm Sci 2006;9(1):1-9. View abstract.

Liu, G. T., Zhang, T. M., Wang, B. E., and Wang, Y. W. Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes. Biochem Pharmacol 1-22-1992;43(2):147-152. View abstract.

Liu, J. J., Lin, D. J., Liu, P. Q., Huang, M., Li, X. D., and Huang, R. W. Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro. J Biomed.Sci 9-6-2006; View abstract.

Liu, J., Kuang, P., Wu, W., Zhang, F., Liu, J., Wan, F., Huang, Y., and Ding, A. Radix Salviae miltiorrhizae protects rat hippocampal neuron in culture from anoxic damage. J Tradit Chin Med 1998;18(1):49-54. View abstract.

Liu, Q. and Chao, R. B. [Determination of danshensu in urine and its pharmacokinetics in human]. Yao Xue.Xue.Bao. 2003;38(10):771-774. View abstract.

Liu, ZL, Gao Sy, Deng J, and Li H. Analysis of effect of composite Danshen droplet pills in treatment of chronic stable angina. Chinese Traditional Patient Medicine 1997;19(7):20-21.

Ma, Z. C., Gao, Y., Tan, H. L., Xiao, C. R., Wu, H. J., and Wang, S. Q. [Effects of fufangdenshen tablets on human atherosclerotic plasma protein using proteomic technique]. Zhongguo Zhong.Yao Za Zhi. 2006;31(9):766-769. View abstract.

Mao, J. and Gan, Z. Observation of Compound Dan Shen dropping pill for cerebral infarction. Pharmacological Magazine of People's Liberation Army 2001;17(1):49-50.

Min, L. Q., Dang, L. Y., and Ma, W. Y. [Clinical study on effect and therapeutical mechanism of composite Salvia injection on acute cerebral infarction]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2002;22(5):353-355. View abstract.

Min, L. Q., Yuan, J., Li, X., and et al. Influence of composite salvia miltiorrhiza on vascular endothelial cell function in patients with cerebral infarction. Chinese Journal of Clinical Rehabilitation 2004;8(16):3090-1.

Oh, S. H., Cho, K. H., Yang, B. S., and Roh, Y. K. Natural compounds from Danshen suppress the activity of hepatic stellate cells. Arch Pharm Res 2006;29(9):762-767. View abstract.

Pan, C., Chen, N., and Huo, J. 187 cases of Compound Dan Shen injection and snake venom for cerebral infarction. 1992;13(2):157-8. Chinese Traditional Medicine of Shanxi 1992;13(2):157-158.

Pei, W. J., Zhao, X. F., Zhu, Z. M., Lin, C. Z., Zhao, W. M., and Zheng, X. H. Study of the determination and pharmacokinetics of Compound Danshen Dripping Pills in human serum by column switching liquid chromatography electrospray ion trap mass spectrometry. J Chromatogr.B Analyt.Technol.Biomed.Life Sci 10-5-2004;809(2):237-242. View abstract.

She, S. F., Huang, X. Z., and Tong, G. D. [Clinical study on treatment of liver fibrosis by different dosages of Salvia injection]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2004;24(1):17-20. View abstract.

Shi, Y. H. [Comparative study of composite danshen droplet pills and sordi in treatment of patients with chronic stable angina]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1997;17(1):23-25. View abstract.

Suh, S. J., Jin, U. H., Choi, H. J., Chang, H. W., Son, J. K., Lee, S. H., Jeon, S. J., Son, K. H., Chang, Y. C., Lee, Y. C., and Kim, C. H. Cryptotanshinone from Salvia miltiorrhiza BUNGE has an inhibitory effect on TNF-alpha-induced matrix metalloproteinase-9 production and HASMC migration via down-regulated NF-kappaB and AP-1. Biochem Pharmacol 12-15-2006;72(12):1680-1689. View abstract.

Sun AY, Zheng P, and Artmann GM. Danshen pretreatment causes pharmacologic and potent resistance to ischemic insult in rat brain. Biorheology 1999;36:73.

Suo, Z., Qin, H., Cao, W., Liu, W., and Zheng, J. [Analysis of four components in Fufang Danshen Tablets by high performance liquid chromatography with electrochemical and ultraviolet detections]. Se.Pu. 2005;23(6):626-629. View abstract.

Tam, L. S., Chan, T. Y., Leung, W. K., and Critchley, J. A. Warfarin interactions with Chinese traditional medicines: danshen and methyl salicylate medicated oil. Aust.N.Z.J Med 1995;25(3):258. View abstract.

Tian, X. H., Xue, W. J., and Ding, X. M. [Application of Danshen injection on early stage of renal transplantation]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2005;25(5):404-407. View abstract.

Wang H. Clinical analysis of 40 cases of hyperlipemia treated by acupoint-injection of Danshen. Chinese Acupuncture & Moxibustion (Chung-Kuo Chen Chiu) 1997;17(8):469-470.

Wang, G., Wang, L., Xiong, Z. Y., Mao, B., and Li, T. Q. Compound salvia pellet, a traditional Chinese medicine, for the treatment of chronic stable angina pectoris compared with nitrates: a meta-analysis. Med Sci.Monit. 2006;12(1):SR1-SR7. View abstract.

Wang, J. Z., Chen, M. E., and Xu, Y. Q. [Effect of Salvia miltiorrhiza co. on angiotensin II and atrial natriuretic polypeptide in rabbits]. Zhong.Xi.Yi.Jie.He.Za Zhi. 1991;11(7):420-1, 390. View abstract.

Wang, X. P. and Yang, R. M. Movement disorders possibly induced by traditional chinese herbs. Eur Neurol 2003;50(3):153-159. View abstract.

Wang, X., Bastow, K. F., Sun, C. M., Lin, Y. L., Yu, H. J., Don, M. J., Wu, T. S., Nakamura, S., and Lee, K. H. Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza. J Med Chem 11-4-2004;47(23):5816-5819. View abstract.

Wang, X., Morris-Natschke, S. L., and Lee, K. H. New developments in the chemistry and biology of the bioactive constituents of Tanshen. Med Res Rev 2007;27(1):133-148. View abstract.

Wasser, S., Ho, J. M., Ang, H. K., and Tan, C. E. Salvia miltiorrhiza reduces experimentally-induced hepatic fibrosis in rats. J Hepatol. 1998;29(5):760-771. View abstract.

Watzke, A., O'Malley, S. J., Bergman, R. G., and Ellman, J. A. Reassignment of the configuration of salvianolic acid B and establishment of its identity with lithospermic acid B. J Nat Prod 2006;69(8):1231-1233. View abstract.

Wei, Z. M. [Effects of injection Salviae miltiorrhizae on senile chronic asthmatic bronchitis patients]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1996;16(7):402-404. View abstract.

Wu, B. W., Pan, T. L., Leu, Y. L., Chang, Y. K., Tai, P. J., Lin, K. H., and Horng, J. T. Antiviral effects of Salvia miltiorrhiza (Danshen) against enterovirus 71. Am J Chin Med 2007;35(1):153-168. View abstract.

Wu, H. L., Wang, X., Li, X. M., Luo, W. J., and Deng, T. T. [Trial study on DENG Tie-tao's coronary heart disease capsules in improving patients' quality of life.]. Chin J Integr.Med 2005;11(3):173-178. View abstract.

Wu, H. N. and Sun, H. [Study on clinical therapeutic effect of composite Salvia injection matched with Western medicine in treating diabetic foot]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23(10):727-729. View abstract.

Wu, W., Kuang, P., and Li, Z. Effect of radix Salviae miltiorrhizae on the gene expression of nitric oxide synthase in ischemic rat brains. J Tradit Chin Med 1998;18(2):128-133. View abstract.

Wu, W., Kuang, P., and Li, Z. Protective effect of radix Salviae miltiorrhizae on apoptosis of neurons during focal cerebral ischemia and reperfusion injury. J Tradit Chin Med 1997;17(3):220-225. View abstract.

Wu, Z. G. and Chen, D. Y. 75 cases of coronary artery disease angina pectoris treated by compound Danshan injection and compound Danshan Drop Pill. J Changchun College Tradit Chin Med 2002;18:14.

Wu, Z. Z., Jiang, Y. Q., Yi, S. M., and Xia, M. T. Radix Salviae Miltiorrhizae in middle and late stage glaucoma. Chin Med.J (Engl.) 1983;96(6):445-447. View abstract.

Xia, Z., Gu, J., Ansley, D. M., Xia, F., and Yu, J. Antioxidant therapy with Salvia miltiorrhiza decreases plasma endothelin-1 and thromboxane B2 after cardiopulmonary bypass in patients with congenital heart disease. J Thorac.Cardiovasc.Surg 2003;126(5):1404-1410. View abstract.

Xiong, L. L. [Therapeutic effect of combined therapy of Salvia miltiorrhizae and Polyporus umbellatus polysaccharide in the treatment of chronic hepatitis B]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1993;13(9):533-537. View abstract.

Xu, Z. C. [Effect of injection Salvia miltiorrhizae on peritoneal dialysis]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1993;13(2):74-6, 67. View abstract.

Yang, M., Liu, A., Guan, S., Sun, J., Xu, M., and Guo, D. Characterization of tanshinones in the roots of Salvia miltiorrhiza (Dan-shen) by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. Rapid Commun.Mass Spectrom. 2006;20(8):1266-1280. View abstract.

Ye, G., Wang, C. S., Li, Y. Y., Ren, H., and Guo, D. A. Simultaneous determination and pharmacokinetic studies on (3,4-Dihydroxyphenyl)-lactic acid and protocatechuic aldehyde in rat serum after oral administration of Radix Salviae miltiorrhizae extract. J Chromatogr.Sci 2003;41(6):327-330. View abstract.

Yi, L. Q. and Wang, X. W. [Comparative study on treatment of severe hepatitis by Western medicine and by TCM]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2002;22(7):543-544. View abstract.

York, D. A., Thomas, S., Greenway, F. L., Liu, Z., and Rood, J. C. Effect of an herbal extract Number Ten (NT) on body weight in rats. Chin Med 2007;2:10. View abstract.

Yu, X. Y., Zhou, Z. W., Lin, S. G., Chen, X., Yu, X. Q., Liang, J., Duan, W., Wen, J. Y., Li, X. T., and Zhou, S. F. Role of ATP-binding cassette drug transporters in the intestinal absorption of tanshinone IIB, one of the major active diterpenoids from the root of Salvia miltiorrhiza. Xenobiotica 2007;37(4):375-415. View abstract.

Yuan, J., Guo, W., Yang, B., Liu, P., Wang, Q., and Yuan, H. 116 cases of coronary angina pectoris treated with powder composed of radix ginseng, radix notoginseng and succinum. J Tradit.Chin Med 1997;17(1):14-17. View abstract.

Zhai, Z. L., Sun, J. H., and Zhang, J. A large dose of Dan Shen for acute ischaemic stroke. HeBei Medicine 2001;7(12):1110-1111.

Zhang, J., Huang, M., Guan, S., Bi, H. C., Pan, Y., Duan, W., Chan, S. Y., Chen, X., Hong, Y. H., Bian, J. S., Yang, H. Y., and Zhou, S. A mechanistic study of the intestinal absorption of cryptotanshinone, the major active constituent of Salvia miltiorrhiza. J Pharmacol Exp Ther 2006;317(3):1285-1294. View abstract.

Zhang, L. F., Li, L., and Li, J. C. Application of improving microcirculation in treating severe acute pancreatitis. Chin J Practl Intern Med 2002;22:163-164.

Zhang, L. J., Zhang, B. F., and Tian, F. Compound Dan Shen combined with heparin for acute ischaemic stroke. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine 2002;12(7):423.

Zhang, R. J., You, C., Cai, B. W., Wan, Y., He, M., and Li, H. [Effect of compound Salvia injection on blood coagulation in patients with traumatic cerebral infarction]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2004;24(10):882-884. View abstract.

Zhang, X. P., Li, Z. J., and Liu, D. R. Progress in research into the mechanism of Radix salviae miltiorrhizae in treatment of acute pancreatitis. Hepatobiliary.Pancreat.Dis Int 2006;5(4):501-504. View abstract.

Zhang, X., Kuang, P., Wu, W., Yin, X., Kanazawa, T., Onodera, K., Metoki, H., and Oike, Y. The effect of radix Salviae Miltiorrhizae Composita on peroxidation of low density lipoprotein due to copper dichloride. J Tradit Chin Med 1994;14(3):195-201. View abstract.

Zhang, X., Wu, W., Kuang, P., Takemichi, K., Kogo, O., Hirobumi, M., and Yasaburo, O. The effect of radix salviae miltiorrhizae composita and ligustrazine on lipid peroxidation in low density lipoprotein due to copper dichloride. J Tradit Chin Med 1994;14(4):292-297. View abstract.

Zhang, Y., Akao, T., Nakamura, N., Duan, C. L., Hattori, M., Yang, X. W., and Liu, J. X. Extremely low bioavailability of magnesium lithospermate B, an active component from Salvia miltiorrhiza, in rat. Planta Med 2004;70(2):138-142. View abstract.

Zhang, Y., Shi, C. X., and Li, Y. X. [Effect of Salviae miltiorrhizae on mRNA expression of inducible nitric oxide synthase and organ injury in rats with severe acute pancreatitis]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2005;25(11):1012-1015. View abstract.

Zheng, G. H. and Kakisawa, H. Research on chemical constituents of Danshen. Zhongguo Yaoxue Zazhi 1989;24:6-10.

Zhou, L., Chow, M., and Zuo, Z. Improved quality control method for Danshen products--consideration of both hydrophilic and lipophilic active components. J Pharm Biomed.Anal. 6-7-2006;41(3):744-750. View abstract.

Zhou, S., Shao, W., and Duan, C. [Observation of preventing and treating effect of Salvia miltiorrhiza composita on patients with ischemic coronary heart disease undergoing non-heart surgery]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1999;19(2):75-76. View abstract.

Zhou, W. and Ruigrok, T. J. Protective effect of danshen during myocardial ischemia and reperfusion: an isolated rat heart study. Am J Chin Med 1990;18(1-2):19-24. View abstract.

Zhou, Z., Liu, Y., Miao, A. D., and Wang, S. Q. Salvianolic acid B attenuates plasminogen activator inhibitor type 1 production in TNF-alpha treated human umbilical vein endothelial cells. J Cell Biochem 9-1-2005;96(1):109-116. View abstract.

Chan TY. Interaction between warfarin and danshen (Salvia miltiorrhiza). Ann Pharmacother 2001;35:501-4. View abstract.

Chan TY. Drug interactions as a cause of overanticoagulation and bleedings in Chinese patients receiving warfarin. Int J Clin Pharmacol Ther 1998;36:403-5. View abstract.

Chow L, Johnson M, Wells A, Dasgupta A. Effect of the traditional Chinese medicines Chan Su, Lu-Shen-Wan, Dan Shen, and Asian ginseng on serum digoxin measurement by Tina-quant (Roche) and Synchron LX system (Beckman) digoxin immunoassays. J Clin Lab Anal 2003;17:22-7. View abstract.

Dasgupta, A., Actor, J. K., Olsen, M., Wells, A., and Datta, P. In vivo digoxin-like immunoreactivity in mice and interference of Chinese medicine Danshen in serum digoxin measurement: elimination of interference by using a chemiluminescent assay. Clin Chim.Acta 2002;317(1-2):231-234. View abstract.

Dr. Duke's Phytochemical and Ethnobotanical Databases. Available at: http://www.ars-grin.gov/duke/.

Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. View abstract.

Izzat MB, Yim APC, El-Zufari MH. A taste of Chinese medicine! Ann Thorac Surg 1998;66:941-2. View abstract.

Qiu F, Wang G, Zhang R, Sun J, et al. Effect of danshen extract on the activity of CYP3A4 in healthy volunteers. Br J Clin Pharmacol 2010;69:656-62. View abstract.

Roberts AT, Martin CK, Liu Z, et al. The safety and efficacy of a dietary herbal supplement and gallic acid for weight loss. J Med Food. 2007;10:184-8. View abstract.

Tam LS, et al. Warfarin interacions with Chinese traditional medicines: danshen and methyl salicylate medicated oil. Aust N Z J Med 1995;25:258.

Tan, K. Q., Zhang, C., Liu, M. X., and Qiu, L. [Comparative study on therapeutic effects of acupuncture, Chinese herbs and Western medicine on nervous tinnitus]. Zhongguo Zhen Jiu 2007;27(4):249-251. View abstract.

Wahed A, Dasgupta A. Positive and negative in vitro interference of Chinese medicine dan shen in serum digoxin measurement. Elimination of interference by monitoring free digoxin concentration. Am J Clin Pathol 2001;116:403-408. View abstract.

Wang N, Luo HW, Niwa M, Ji J. A new platelet aggregation inhibitor from Salvia miltiorrhiza. Planta Med 1989;55:390-1.

Wu B, Liu M, Zhang S. Dan Shen agents for acute ischaemic stroke. Cochrane Database Syst Rev 2007;(2):CD004295. View abstract.

Xue, Y. P., Zhang, S. B., and Gao, T. [Observation on therapeutic effect of chronic prostatitis treated mainly by warming needle moxibustion]. Zhongguo Zhen Jiu 2006;26(5):335-336. View abstract.

Yu CM, Chan JC, Sanderson JE. Chinese herbs and warfarin potentiation by danshen. J Intern Med 1997;241:337-9. View abstract.

Health Solutions From Our Sponsors