Diabetes: Diabetic Peripheral Neuropathy Treatment

Reviewed on 12/19/2020

What Is It?

Diabetic peripheral neuropathy can affect people who have type 1 and type 2 diabetes.

Nerve damage, what doctors call neuropathy, is a common complication of both type 1 and type 2 diabetes. Peripheral means the nerves in your feet, hands, legs, or arms are affected. Diabetic peripheral neuropathy (DPN) can feel like tingling, burning, pins and needles, stabbing, or even numbness. If you're also overweight or have high blood pressure, high triglyceride levels, or plaque buildup in your heart's arteries, your odds of DPN go up.

Manage Your Numbers

High blood sugar damages nerves and blood vessels so keep your numbers within a healthy range.

High blood sugar over time damages nerves and the small blood vessels that support them. When your blood sugar level is consistently in the normal range, you lower the chance of complications like DPN and help stop it from getting worse. Follow your doctor's instructions about taking medicine or insulin as well as other steps to control your glucose.


Exercise helps maintain balance and strength and it may even reverse symptoms.

Moderate physical activity can delay problems and even reverse symptoms. Aside from that, it helps your balance and strength, so you're less likely to fall. Adults shouldn't skip exercise for more than 2 days in a row and get a total of at least 150 minutes a week. Brisk walks are a great way to start if you aren't working out regularly yet.

Stop Smoking

Smoking lowers oxygen levels and creates free radicals, both of which are bad for your nerves.

It's linked to low oxygen in your blood, which means tissues like your blood vessels and nerves may not get enough oxygen either. It also creates "free radicals" that can damage cells, harms the lining of blood vessels, makes it harder to control your blood sugar, and causes inflammation. All of this can lead to DPN or make it worse.

Eat Healthy

A healthy diet is best for your weight, blood sugar levels, and nerves.

Fruits, vegetables, whole grains, low-fat dairy, lean proteins, fish, and high-fiber and low-salt foods are good for you whether you have diabetes or not. Good nutrition helps keep your body strong and working well. That includes your nerve endings and blood vessels. Eating well is also important to manage your weight and blood sugar.

Vitamins D and B12

Adequate levels of vitamin D and vitamin B12 may help protect against DPN.

People who don't get enough of these tend to develop DPN. Sunlight is a good source of vitamin D, as are cheese, egg yolks, mushrooms, and fatty fish like tuna, salmon, and mackerel. Fish and red meat have vitamin B12. Some foods have these vitamins added, too, like orange juice, soy milk, and cereals. Taking vitamin D supplements when you have DPN may ease symptoms, but it doesn't look like B12 supplements help.


Antidepressants and anti-seizure meds may help relieve DPN pain.

Over-the-counter pain relievers like ibuprofen don't usually work for DPN. But some prescription medicines that treat depression and seizures -- including duloxetine, gabapentin, pregabalin, and tricyclic antidepressants -- might make it hurt less. You often take them at night so you sleep better. They can have unpleasant side effects though, so talk to your doctor about what the right choice is for you.


Topical capsaicin may help relieve pain associated with DPN.

Put it on your skin in a cream, ointment, or patch, and it breaks down substances in nerve endings around there so they can't send pain signals. One study found that people who used a capsaicin patch one time for 60 minutes had pain relief for up to 12 weeks. This is the chemical that makes peppers hot, and it can burn a little when you apply it.


ALA and acetyl-L-carnitine may help protect nerves and reduce pain.

More research is needed, but early studies suggest that the antioxidants alpha-lipoic acid (ALA) and acetyl-L-carnitine may protect and repair nerves and lessen pain. Check with your doctor before you start taking these because they can cause problems for some people and with some medications.


Acupuncture may help relieve DPN pain and encourage nerve healing.

One study found it to be better than traditional medication for DPN symptoms, and typically with few side effects. It may work by triggering your body to use the energy and chemistry of your immune system to help heal and reduce pain. Look for a certified practitioner if you want to try it.

Relaxation and Meditation

Relaxation strategies may reduce stress and help you manage DPN better.

Practices such as yoga, massage, guided imagery, deep breathing exercises, tai chi, even hypnosis can help lower your heart rate, blood pressure, and other signs of stress that make chronic pain and discomfort harder to manage. Scientific results are mixed, but many people find these types of complementary treatments effective.

Essential Oils

Essential oils may help you manage pain and the stress of having a chronic condition.

Extracts from plants including rosemary, lavender, eucalyptus, chamomile, and peppermint can be rubbed on your skin or used in aromatherapy to manage pain. They may also ease the stress that comes from dealing with a condition that can't be cured. A word of caution: When you put essential oils directly on your skin, they probably should be mixed with another oil to dilute them.

Treat Your Feet Gently

Guard against injury if you have nerve damage.

Because nerve damage can make it harder to tell when something's wrong, try to avoid injuring your feet. Don't walk around barefoot. Make sure your shoes fit properly, and break new ones in slowly. Wear a fresh pair of cotton socks each day. Be careful trimming toenails. Check your feet daily for cracks, blisters, and sores; get a full professional exam at least once a year.

Warm Bath With Epsom Salts?

Bathing in Epsom salts is not advised with DPN because it may dry out your skin and lead to cracking and irritation.

Although it may be soothing, it's not recommended. Soaking can dry your skin, cause irritation, and open cracks that could become infected. You might also scald your skin in water that's too hot.

You should still wash your feet in lukewarm water every day.


Biofeedback teaches you how to lower your heart rate and blood pressure and reduce stress.

Chronic pain is one of several conditions this therapy is used for. While you learn relaxation techniques, your vital signs, like heart rate and blood pressure, are tracked with sensors. You see your results on a screen so you can tell how well you're doing. You work toward getting the same results without the monitoring equipment.


There is little evidence that a TENS unit is an effective treatment for DPN.

For severe pain, your doctor might suggest transcutaneous electrical nerve stimulation. You use a device that sends small electrical pulses through your skin either near where it hurts or at your spine. The idea is to block or confuse the pain-triggering messages your body is sending to your brain. It's generally safe, but there's little evidence this treatment is effective for DPN.

Diabetes: Diabetic Peripheral Neuropathy Treatment

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