- What other names is Dibencozide known by?
- What is Dibencozide?
- How does Dibencozide work?
- Are there safety concerns?
- Are there any interactions with medications?
- Dosing considerations for Dibencozide.
Adenosylcobalamin, Adénosylcobalamine, Cobalamin Enzyme, Cobalamine, Cobamamide, Coenzyme B12, Co-Enzyme B12, Coenzyme B-12, Co-Enzyme B-12, Dibencozida.
Dibencozide is a form of vitamin B12. People use it as medicine.
When taken by mouth or placed under the tongue, dibencozide is used to help the body process protein; increase muscle mass and strength; improve mental concentration; and to treat depression, anxiety, and panic attacks.
Insufficient Evidence to Rate Effectiveness for...
- Helping the body process protein.
- Increasing muscle mass and strength.
- Improving mental concentration.
- Panic attacks.
- Other conditions.
Dibencozide is a form of vitamin B12. Vitamin B12 is important in chemical reactions throughout the body. However, dibencozide is not as stable as cyanocobalamin, the form of vitamin B12 most often found in vitamin tablets, and may break down during storage.
Dibencozide seems to be safe for most people. There are no reported side effects.
Special Precautions & Warnings:Pregnancy and breast-feeding: Not enough is known about the use of dibencozide during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Gastrointestinal (GI) conditions: Some GI conditions, such as ileal disease or surgical removal of part of the intestine, can reduce that amount of Vitamin B12, including dibencozide, that is absorbed from the intestine.
ChloramphenicolInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Dibencozide is a form of vitamin B12. Vitamin B12 is important for producing new blood cells. Chloramphenicol might decrease new blood cells. Taking chloramphenicol for a long time might decrease the effects of dibencozide on new blood cells. But most people only take chloramphenicol for a short time so this interaction isn't a big problem.
The appropriate dose of dibencozide depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for dibencozide. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
Health Solutions From Our Sponsors
Andres E, Noel E, Goichot B. Metformin-associated vitamin B12 deficiency (letter). Arch Intern Med 2002;162:2251-2. View abstract.
Aymard JP, Aymard B, Netter P, et al. Haematological adverse effects of histamine H2-receptor antagonists. Med Toxicol Adverse Drug Exp 1988;3:430-48. View abstract.
Barone C, Bartoloni C, Ghirlanda G, Gentiloni N. Megaloblastic anemia due to folic acid deficiency after oral contraceptives. Haematologica 1979;64:190-5. View abstract.
Bauman WA, Shaw S, Jayatilleke E, et al. Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care 2000;23:1227-31. View abstract.
Bauman WA, Spungen AM, Shaw S, et al. Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care 2000;23:1227-31. View abstract.
Belaiche J, Zittoun J, Marquet J, et al. Effect of ranitidine on secretion of gastric intrinsic factor and absorption of vitamin B12. Gastroenterol Clin Biol 1983;7:381-4. View abstract.
Bellou A, Aimone-Gastin I, De Korwin JD, et al. Cobalamin deficiency with megaloblastic anaemia in one patient under long-term omeprazole therapy. J Intern Med 1996;240:161-4. View abstract.
Beltz SD, Doering PL. Efficacy of nutritional supplements used by athletes. Clin Pharm 1993;12:900-8. View abstract.
Callaghan TS, Hadden DR, Tomkin GH. Megaloblastic anemia due to vitamin B12 malabsorption associated with longterm metformin treatment. Br Med J 1980;280:1214-5. View abstract.
Carlsen SM, Folling I, Grill V, et al. Metformin increases total homocysteine levels in non-diabetic male patients with coronary heart disease. Scand J Clin Lab Invest 1997;57:521-7. View abstract.
Carpentier JL, Bury J, Luyckx A, et al. Vitamin B12 and folic acid serum levels in diabetics under various therapeutic regimens. Diabete Metab 1976;2:187-90. View abstract.
Coronato A, Glass GB. Depression of the intestinal uptake of radio-vitamin B12 by cholestyramine. Proc Soc Exp Biol Med 1973;142:1341-4. View abstract.
Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
Ehrenfeld M, Levy M, Sharon P, et al. Gastrointestinal effects of long-term colchicine therapy in patients with recurrent polyserositis (Familial Mediterranean Fever). Dig Dis Sci 1982;27:723-7. View abstract.
Falguera M, Perez-Mur J, Puig T, Cao G. Study of the role of vitamin B12 and folinic acid supplementation in preventing hematologic toxicity of zidovudine. Eur J Haematol 1995;55:97-102. View abstract.
Faloon WW, Chodos RB. Vitamin B12 absorption studies using cochicines, neomycin and continuous 57Co B12 administration. Gastroenterology 1969;56:1251.
Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://books.nap.edu/books/0309065542/html/.
Force RW, Meeker AD, Cady PS, et al. Increased vitamin B12 requirement associated with chronic acid suppression therapy. Ann Pharmacother 2003;37:490-3. View abstract.
Force RW, Nahata MC. Effect of histamine H2 receptor antagonists on vitamin B12 absorption. Ann Pharmacother 1992;26:1283-6. View abstract.
Frenkel EP, McCall MS, Sheehan RG. Cerebrospinal fluid folate and vitamin B12 in anticonvulsant-induced megaloblastosis. J Lab Clin Med 1973;81:105-15. View abstract.
Gardyn J, Mittelman M, Zlotnik J, et al. Oral contraceptives can cause falsely low vitamin B12 levels. Acta Haematol 2000;104:22-4. View abstract.
Gharakhanian S, Navarette MS, Cardon B, Rozenbaum W. Vitamin B12 injections in patients treated with zidovudine. AIDS 1990;4:701-2. View abstract.
Gilligan MA. Metformin and vitamin B12 deficiency (letter). Arch Intern Med 2002;162:484-5. View abstract.
Gilman AG, et al, eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY: Pergamon Press, 1990.
Goldin BR, Lichtenstein AH, Gorbach SL. Nutritional and metabolic roles of intestinal flora. In: Shils ME, Olson JA, Shike M, eds. Modern Nutrition in Health and Disease, 8th ed. Malvern, PA: Lea & Febiger, 1994.
Gorbach SL. Bengt E. Gustafsson memorial lecture. Function of the normal human microflora. Scand J Infect Dis Suppl 1986;49:17-30. View abstract.
Grace E, Emans SJ, Drum DE. Hematologic abnormalities in adolescents who take oral contraceptive pills. J Pediatrics 1982;101:771-4. View abstract.
Halsted CH, McIntyre PA. Intestinal malabsorption caused by aminosalicylic acid therapy. Arch Int Med 1972;130;935-9. View abstract.
Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
Herbert V, Jacob E. Destruction of vitamin B12 by ascorbic acid. JAMA 1974;230:241-2. View abstract.
Hielt K, Brynskov J, Hippe E, et al. Oral contraceptives and the cobalamin (vitamin B12) metabolism. Acta Obstet Gynecol Scand 1985;64:59-63. View abstract.
Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5. View abstract.
Jacobson ED, Faloon WW. Malabsorptive effects of neomycin in commonly used doses. JAMA 1961;175:187-90. View abstract.
Kinsella LJ, Green R. Anesthesia paresthetica: nitrous oxide-induced cobalamin deficiency. Neurology 1995;45:1608-10. View abstract.
Lees F. Radioactive vitamin B12 absorption in the megaloblastic anemia caused by anticonvulsant drugs. Q J Med 1961;30:231-48. View abstract.
Leonard JP, Desager JP, Beckers C, Harvengt C. In vitro binding of various biological substances by two hypocholesterolemic resins. Arzneimittelforschung 1979;29:97-81. View abstract.
Line DH, Seitanidis B, Morgan JO, Hoffbrand AV. The effects of chemotherapy on iron, folate, and vitamin B12 metabolism in tuberculosis. Q J Med 1971;40:331-40. View abstract.
Marcuard SP, Albernaz L, Khazaine PG. Omeprazole therapy causes malabsorption of cyanocobalamin. Ann Intern Med 1994;120:211-5. View abstract.
Marie RM, Le Biez E, Busson P, et al. Nitrous-oxide anesthesia-associated myelopathy. Arch Neurol 2000;57:380-2. View abstract.
Mooij PN, Thomas CM, Doesburg WH, Eskes TK. Multivitamin supplementation in oral contraceptive users. Contraception 1991;44:277-88. View abstract.
Package insert for Paser granules. Jacobus Pharmaceutical Co., Inc. Princeton, NJ. July 1996.
Paltiel O, Falutz J, Veilleux M, et al. Clinical correlates of subnormal vitamin B12 levels in patients infected with the human immunodeficiency virus. Am J Hematol 1995;49:318-22. View abstract.
Prasad AS, Lei KY, Moghissi KS, et al. Effect of oral contraceptives on nutrients. III. Vitamins B6, B12 and folic acid. Am J Obstet Gynecol 1976;125:1063-9. View abstract.
Race TF, Paes IC, Faloon WW. Intestinal malabsorption induced by oral colchicine. Comparison with neomycin and cathartic agents. Am J Med Sci 1970;259:32-41. View abstract.
Reynolds EH, Hallpike JF, Phillips BM, et al. Reversible absorptive defects in anticonvulsant megaloblastic anemia. J Clin Pathol 1965;18:593-8. View abstract.
Reynolds EH. Schizophrenia-like psychoses of epilepsy and disturbances of folate and vitamin B12 metabolism induced by anticonvulsant drugs. Br J Psychiatry 1967;113:911-9. View abstract.
Richman DD, Fischl MA, Grieco MH, et al. The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. N Engl J Med 1987;317:192-7. View abstract.
Ruscin JM, Page RL, Valuck RJ. Vitamin B12 deficiency associated with histamine-2-receptor antagonists and a proton-pump inhibitor. Ann Pharmacother 2002;36:812-6. View abstract.
Salom IL, Silvis SE, Doscherholmen A. Effect of cimetidine on the absorption of vitamin B12. Scand J Gastroenterol 1982;17:129-31. View abstract.
Saltzman JR, Kemp JA, Golner BB, et al. Effect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption. J Am Coll Nutr 1994;13:584-91. View abstract.
Shojania AM. Oral contraceptives: effect on folate and vitamin B12 metabolism. Can Med Assoc J 1982;126:244-7. View abstract.
Termanini B, Gibril F, Sutliff VE, et al. Effect of long-term gastric acid suppressive therapy on serum vitamin B12 levels in patients with Zollinger-Ellison syndrome. Am J Med 1998;104:422-30. View abstract.
Toskes PP, Deren JJ. Selective inhibition of vitamin B12 absorption by para-aminosalicylic acid. Gastroenterology 1972;62:1232-7. View abstract.
Tyrer LB. Nutrition and the pill. J Reprod Med 1984;29:547-50.. View abstract.
Webb DI, Chodos RB, Mahar CQ, et al. Mechanism of vitamin B12 malabsorption in patients receiving colchicine. N Engl J Med 1968;279:845-50. View abstract.
West RJ, Lloyd JK. The effect of cholestyramine on intestinal absorption. Gut 1975;16:93-8. View abstract.