Other Name(s):

3,5 diiodothyronine; 3,5-diiodo-L-thyronine; 3,5-L-diiodothyronine; 3,5-T2; Diyodotironina; T2; T-2.

Overview
Uses
Side Effects
Precautions
Dosing

Overview

Diiodothyronine is a hormone. It is used as medicine.

People take diiodothyronine to lose weight, treat high cholesterol, and enhance bodybuilding.

How does it work?

Some animal and test tube research suggests that diiodothyronine might speed up metabolism and reduce fat storage. But there is no reliable research in people, so no one knows if diiodothyronine has these effects in people.

Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

Weight loss.
High cholesterol.
Improving bodybuilding.
Other conditions.

More evidence is needed to rate the effectiveness of diiodothyronine for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

SLIDESHOW

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Side Effects

There isn't enough information to know if diiodothyronine is safe.

Special Precautions & Warnings

Pregnancy and breast-feeding: Not enough is known about the use of diiodothyronine during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Dosing

The appropriate dose of diiodothyronine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for diiodothyronine. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Reviewed on 6/14/2021

References

Ball SG, Sokolov J, Chin WW. 3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitro. J Mol Endocrinol 1997;19:137-47. View abstract.

Giudetti AM, Leo M, Geelen MJ, Gnoni GV. Short-term stimulation of lipogenesis by 3,5-L-diiodothyronine in cultured rat hepatocytes. Endocrinology 2005;146:3959-66. View abstract.

Goglia F. Biological effects of 3,5-diiodothyronine (T(2)). Biochemistry (Mosc) 2005;70:164-72. View abstract.

Lanni A, Moreno M, Lombardi A, et al. 3,5-diiodo-L-thyronine powerfully reduces adiposity in rats by increasing the burning of fats. FASEB J 2005;19:1552-4. View abstract.

Moreno M, Lombardi A, Lombardi P, et al. Effect of 3,5-diiodo-L-thyronine on thyroid stimulating hormone and growth hormone serum levels in hypothyroid rats. Life Sci 1998;62:2369-77. View abstract.

Silvestri E, Schiavo L, Lombardi A, Goglia F. Thyroid hormones as molecular determinants of thermogenesis. Acta Physiol Scand 2005;184:265-83. View abstract.