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Medications and Drugs

Brand Names: Ultracet

Generic Name: acetaminophen and tramadol (Pronunciation: a SEET a MIN o fen and TRAM a dol)

What is acetaminophen and tramadol (Ultracet)?

Tramadol is a narcotic-like pain reliever. Acetaminophen is a less potent pain reliever that increases the effects of tramadol.

The combination of acetaminophen and tramadol is used to treat moderate to severe pain.

Acetaminophen and tramadol may also be used for purposes not listed in this medication guide.

Acetaminophen-Tramadol 325 mg-37.5 mg-IVA

oblong, yellow, imprinted with 650, O M

Acetaminophen-Tramadol 325 mg-37.5 mg-PAR

oblong, orange, imprinted with 083, KALI

APAP-Tramadol 37.5-325 mg-CAR

oblong, yellow, imprinted with 537


oblong, yellow, imprinted with O-M, 650

What are the possible side effects of acetaminophen and tramadol (Ultracet)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using acetaminophen and tramadol and call your doctor at once if you have any of these serious side effects:

  • seizure (convulsions);
  • agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting;
  • a red, blistering, peeling skin rash; or
  • shallow breathing, weak pulse.

Less serious side effects may include:

  • dizziness, drowsiness, weakness, tired feeling;
  • stomach pain, constipation, loss of appetite;
  • dry mouth, blurred vision;
  • feeling nervous or anxious;
  • sweating, itching; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about acetaminophen and tramadol (Ultracet)?

Tell your doctor if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen.

Do not take more of this medication than is recommended. An acetaminophen and tramadol overdose can damage your liver or cause death. The maximum amount of acetaminophen and tramadol is 2 tablets per dose, or 8 tablets per day.

You should not take this medication if you are allergic to acetaminophen and tramadol, if you are intoxicated (drunk), or if you have recently used narcotic pain medicine, a sedative or tranquilizer, medicine for depression or mental illness, or any type of street drug.

Do not drink alcohol while you are taking acetaminophen and tramadol. Alcohol may cause a dangerous decrease in your breathing when used together with acetaminophen and tramadol. Alcohol may also increase your risk of liver damage while taking acetaminophen.

Acetaminophen and tramadol may be habit-forming and should be used only by the person it was prescribed for. Never share this medication with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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