allopurinol (Aloprim, Lopurin, Zyloprim)

Brand Names: Aloprim, Lopurin, Zyloprim

Generic Name: allopurinol

What is allopurinol (Aloprim, Lopurin, Zyloprim)?

Allopurinol reduces the production of uric acid in the body.

Allopurinol is used to treat gout or kidney stones.

Allopurinol is also used to decrease levels of uric acid in people who are receiving cancer treatment.

Allopurinol may also be used for purposes not listed in this medication guide.

What are the possible side effects of allopurinol (Aloprim, Lopurin, Zyloprim)?

Stop using this medicine and get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Stop using allopurinol and call your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about allopurinol (Aloprim, Lopurin, Zyloprim)?

You should not use this medicine if you have ever had a serious allergic reaction to allopurinol. Stop taking the medicine and call your doctor at once if you have any signs of skin rash (no matter how mild), painful urination, blood in your urine, burning in your eyes, or swelling in your face or throat.

What should I discuss with my healthcare provider before using allopurinol (Aloprim, Lopurin, Zyloprim)?

You should not use allopurinol if you are allergic to it.

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

Do not give this medicine to a child without medical advice.

How should I use allopurinol (Aloprim, Lopurin, Zyloprim)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Allopurinol oral is taken by mouth.

Take allopurinol oral with a full glass of water. To reduce your risk of kidney stones forming, drink 8 to 10 full glasses of fluid every day, unless your doctor tells you otherwise.

Take allopurinol oral after a meal if allopurinol upsets your stomach.

Allopurinol injection is given as an infusion into a vein if you are unable to take the medicine by mouth. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

You may need to mix allopurinol injection with a liquid (diluent) in an IV bag. When using injections by yourself, be sure you understand how to properly mix and store the medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Prepare an injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective.

You may have gout attacks more often when you first start taking allopurinol oral. Your doctor may recommend other gout medication to take with allopurinol. Keep taking the medicine as directed.

It may take 2 to 6 weeks before you have fewer gout attacks. Call your doctor if your symptoms do not improve after 6 weeks.

You may need to follow a special diet to help prevent kidney stones. Follow all instructions of your doctor or dietitian. Learn about the foods to eat or avoid.

Store at room temperature away from moisture and heat.


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What happens if I miss a dose (Aloprim, Lopurin, Zyloprim)?

Take the allopurinol oral dose as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Call your doctor for instructions if you miss an allopurinol injection.

What happens if I overdose (Aloprim, Lopurin, Zyloprim)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using allopurinol (Aloprim, Lopurin, Zyloprim)?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Avoid drinking alcohol. It may worsen your condition.

What other drugs will affect allopurinol (Aloprim, Lopurin, Zyloprim)?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect allopurinol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Aloprim, Lopurin, Zyloprim)?

Your pharmacist can provide more information about allopurinol.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 10/12/2022

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