Medications and Drugs
Brand Names: Saphris
Generic Name: asenapine (Pronunciation: a SEN a peen)
What is asenapine (Saphris)?
Asenapine is an antipsychotic medication. It works by changing the actions of chemicals in the brain.
Asenapine may also be used for purposes not listed in this medication guide.
Saphris 10 mg
round, white, imprinted with 10
Saphris 5 mg
round, white, imprinted with 5
What are the possible side effects of asenapine (Saphris)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using asenapine and call your doctor at once if you have any of these serious side effects:
Less serious side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about asenapine (Saphris)?
Asenapine is not for use in psychotic conditions related to dementia. Asenapine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.
While you are taking asenapine, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking asenapine.
Asenapine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Before taking asenapine, tell your doctor if you have liver disease, heart disease, high blood pressure, seizures, low white blood cell counts, diabetes, trouble swallowing, or a history of breast cancer, heart attack, stroke, or "Long QT syndrome."
Drinking alcohol can increase some of the side effects of asenapine.
Stop taking asenapine and call your doctor at once if you have fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, restless muscle movements in your face or neck, tremor (uncontrolled shaking), trouble swallowing, feeling light-headed, or fainting.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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