asparaginase Erwinia chrysanthemi (Erwinase, Erwinaze, Rylaze)

Brand Names: Erwinaze

Generic Name: asparaginase Erwinia chrysanthemi

What is asparaginase Erwinia chrysanthemi (Erwinaze)?

Asparaginase Erwinia chrysanthemi is used to treat acute lymphoblastic leukemia (ALL).

Asparaginase Erwinia chrysanthemi may also be used for purposes not listed in this medication guide.

What are the possible side effects of asparaginase Erwinia chrysanthemi (Erwinaze)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe pain in your upper stomach spreading to your back, nausea and vomiting;
  • easy bruising, unusual bleeding, purple or red spots under your skin;
  • any bleeding that will not stop;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or
  • signs of a blood clot--sudden numbness or weakness (especially on one side of the body), slurred speech, balance problems, chest pain, sudden cough, rapid breathing, coughing up blood.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about asparaginase Erwinia chrysanthemi (Erwinaze)?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What should I discuss with my healthcare provider before using asparaginase Erwinia chrysanthemi (Erwinaze)?

You should not receive asparaginase Erwinia chrysanthemi if you are allergic to it, or if you have received asparaginase (Elspar) in the past and it caused you to have:

  • serious pancreas problems;
  • a blood clot; or
  • serious bleeding problems.

Tell your doctor if you have ever had:

  • diabetes;
  • a bleeding or blood clotting disorder such as hemophilia;
  • blood clots; or
  • pancreas problems.

You may need to have a negative pregnancy test before starting this treatment.

Asparaginase Erwinia chrysanthemi may harm an unborn baby. Use effective birth control to prevent pregnancy. Keep using birth control for at least 3 months after your last dose. Tell your doctor if you become pregnant.

Asparaginase Erwinia chrysanthemi can make birth control pills less effective. Ask your doctor about using a non-oral birth control to prevent pregnancy. This includes injections, implants, skin patches, vaginal rings, condom, diaphragm, cervical cap, or contraceptive sponge.

You should not breastfeed while using asparaginase Erwinia chrysanthemi, and for at least 3 months after your last dose.

How should I use asparaginase Erwinia chrysanthemi (Erwinaze)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Asparaginase Erwinia chrysanthemi is injected into a muscle, or as an infusion into a vein. A healthcare provider may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Prepare an injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Store unopened vials (bottles) in the refrigerator. Protect from light.

Store mixed medicine at room temperature and use it within 4 hours. Do not refrigerate or freeze after mixing.


What causes tooth decay? See Answer

What happens if I miss a dose (Erwinaze)?

Call your doctor for instructions if you miss a dose.

What happens if I overdose (Erwinaze)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using asparaginase Erwinia chrysanthemi (Erwinaze)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect asparaginase Erwinia chrysanthemi (Erwinaze)?

Other drugs may affect asparaginase Erwinia chrysanthemi, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information (Erwinaze)?

Your doctor or pharmacist can provide more information about asparaginase Erwinia chrysanthemi.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Health Solutions From Our Sponsors

Reviewed on 3/17/2022

Health Solutions From Our Sponsors