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Medications and Drugs

Brand Names: Simulect

Generic Name: basiliximab (Pronunciation: bass il IX im ab)

What is basiliximab (Simulect)?

Basiliximab lowers your body's immune system. The immune system helps your body fight infections. The immune system can also fight or "reject" a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader.

Basiliximab is used with other medications to prevent organ rejection after a kidney transplant.

Basiliximab may also be used for purposes not listed in this medication guide.

What are the possible side effects of basiliximab (Simulect)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing, difficult breathing and/or sneezing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • pain or burning when you urinate;
  • easy bruising or bleeding, unusual weakness;
  • tremors, shaking;
  • fever, chills, body aches, flu symptoms, vomiting, diarrhea;
  • trouble breathing;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling); or
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling).

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about basiliximab (Simulect)?

You should not use basiliximab if you are allergic to it.

Before you receive this medicine, tell your doctor if you have cancer, diabetes, high cholesterol, or high or low levels of potassium in your blood.

Basiliximab can lower blood cells that help your body fight infections and help your blood clot. Your blood may need to be tested often. Avoid being near people who are sick or have infections. Avoid activities that may increase your risk of bleeding injury. Tell your doctor at once if you develop signs of infection.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Avoid receiving a vaccine shortly after you have been treated with basiliximab, unless your doctor has told you to.

There may be other drugs that can interact with basiliximab. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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