bempedoic acid and ezetimibe (Nexlizet)

Brand Names: Nexlizet

Generic Name: bempedoic acid and ezetimibe

What is bempedoic acid and ezetimibe (Nexlizet)?

Bempedoic acid and ezetimibe is a combination medicine that is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL).

Bempedoic acid and ezetimibe is used together with a low-fat diet and other medicines to lower LDL cholesterol in adults with an inherited form of high cholesterol. This medicine is also used in adults with heart disease who need additional lowering of LDL cholesterol.

It is not known whether this medicine reduces your risk of heart attack, stroke, or death.

Bempedoic acid and ezetimibe may also be used for purposes not listed in this medication guide.

What are the possible side effects of bempedoic acid and ezetimibe (Nexlizet)?

Get emergency medical help if you have signs of an allergic reaction: hives, rash, severe itching, skin redness or swelling; wheezing, difficult breathing, feeling light-headed; fast or pounding heartbeats; swelling of your face, lips, tongue, or throat.

Some side effects of bempedoic acid and ezetimibe can occur weeks or months after you have started taking this medicine.

Stop taking this medicine and get medical help right away if you have signs of tendon rupture--sudden pain, swelling, bruising, tenderness, stiffness, movement problems, or a snapping or popping sound in any of your joints (rest the joint until you receive medical care or instructions).

Call your doctor at once if you have:

  • low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or
  • symptoms of gout--joint pain or swelling, warmth or redness around your joints, severe foot or toe pain.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about bempedoic acid and ezetimibe (Nexlizet)?

Some cholesterol medications should not be taken at the same time. If you take ezetimibe with another cholesterol medicine, follow your doctor's dosing instructions very carefully.

What should I discuss with my healthcare provider before taking bempedoic acid and ezetimibe (Nexlizet)?

You should not use this medicine if you are allergic to bempedoic acid or ezetimibe.

You may not be able to use bempedoic acid and ezetimibe if you have severe liver or kidney disease, or if you are on dialysis.

This medicine may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the arm, shoulder, or Achilles' tendon of the heel. This can happen during treatment or several weeks after you start taking bempedoic acid and ezetimibe. Tendon problems may be more likely if you are older than 60, if you have kidney failure, if you already have tendon problems, or if you use steroid medicine or certain antibiotics (such as Cipro or Levaquin).

Tell your doctor if you have ever had:

It is not known whether this medicine will harm an unborn baby. Tell your doctor right away if you become pregnant.

You should not breastfeed while using this medicine.

Bempedoic acid and ezetimibe is not approved for use by anyone younger than 18 years old.

How should I take bempedoic acid and ezetimibe (Nexlizet)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

You may take this medicine with or without food.

Swallow the tablet whole and do not crush, chew, or break it.

You will need frequent medical tests.

Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.


How to Lower Your Cholesterol & Save Your Heart See Slideshow

What happens if I miss a dose (Nexlizet)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose (Nexlizet)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking bempedoic acid and ezetimibe (Nexlizet)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect bempedoic acid and ezetimibe (Nexlizet)?

Ask your doctor before using pravastatin or simvastatin. Statin medications can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Your doctor may need to adjust the doses of pravastatin or simvastatin if you take either medicine with bempedoic acid and ezetimibe.

If you take any of the following medicines, take your bempedoic acid and ezetimibe dose 2 hours before or 4 hours after you take the other medicine:

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect bempedoic acid and ezetimibe, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Nexlizet)?

Your pharmacist can provide more information about bempedoic acid and ezetimibe.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 10/12/2022

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