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Medications and Drugs

Brand Names: Angiomax

Generic Name: bivalirudin (Pronunciation: bye VAL i roo din)

What is bivalirudin (Angiomax)?

Bivalirudin keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions.

Bivalirudin is used to prevent blood clots in people with severe chest pain or other conditions who are undergoing a procedure called angioplasty (to open blocked arteries).

Bivalirudin may also be used for purposes not listed in this medication guide.

What are the possible side effects of bivalirudin (Angiomax)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have:

  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • slow heart rate;
  • increased blood pressure (severe headache, blurred vision, buzzing in your ears, confusion, shortness of breath);
  • decreased blood pressure (feeling like you might pass out);
  • sudden numbness or weakness, especially on one side of the body;
  • sudden headache, confusion, problems with vision, speech, or balance;
  • pain or swelling in one or both legs;
  • chest pain;
  • any bleeding that will not stop;
  • black, bloody, or tarry stools;
  • coughing up blood or vomit that looks like coffee grounds; or
  • little or no urinating.

Common side effects may include:

  • headache, anxiety;
  • nausea, vomiting;
  • pelvic pain, back pain;
  • sleep problems (insomnia); or
  • pain or irritation where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about bivalirudin (Angiomax)?

You should not receive bivalirudin if you are allergic to it, or if you have any major bleeding from a surgery, injury, or other medical trauma.

Bivalirudin is not expected to be harmful to an unborn baby. However, aspirin is usually given with bivalirudin, and aspirin can cause bleeding when it is taken during the last 3 months of pregnancy. Aspirin can also cause side effects in a newborn baby.

Tell your doctor if you are pregnant before you are treated with bivalirudin and aspirin.

Before using bivalirudin, tell your doctor if you are allergic to any drugs, or if you have heart disease, kidney disease, or a bleeding or blood clotting disorder such as hemophilia.

Tell your doctor if you are using blood thinners or receiving any other medications to treat or prevent blood clots.

Because bivalirudin keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it may be easier for you to bleed even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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