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bleomycin (Blenoxane)

Brand Names: Blenoxane

Generic Name: bleomycin

What is bleomycin (Blenoxane)?

Bleomycin is used to treat:

Bleomycin may also be used for purposes not listed in this medication guide.

What are the possible side effects of bleomycin (Blenoxane)?

Get emergency medical help if you have signs of an allergic reaction: hives; fever, chills, confusion; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

Bleomycin can cause life-threatening breathing problems. While you are being treated with this medicine, be sure you can get medical help quickly in case you have any serious side effects.

Call your doctor at once if you have:

  • sudden chest pain, shortness of breath, dry cough, tiredness;
  • a light-headed feeling, feeling like you might pass out;
  • loss of appetite, weight loss;
  • sudden numbness or weakness on one side of the body, problems with vision or speech;
  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
  • unusual hardening of your skin; or
  • swelling, numbness, tingling or cold feeling in your fingers.

Serious side effects may be more likely in older adults.

Common side effects may include:

  • skin redness, dark streaks, or discoloration;
  • fingernail or toenail changes;
  • fever, chills, vomiting, not feeling well;
  • rash, itching; or
  • hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about bleomycin (Blenoxane)?

While you are being treated with this medicine, be sure you can get medical help quickly in case you have any serious side effects.

Call your doctor at once if you feel tired, light-headed, or short of breath, or if you have chest pain or discomfort, a dry cough, a decreased appetite, or weight loss.

What should I discuss with my healthcare provider before receiving bleomycin (Blenoxane)?

You should not be treated with bleomycin if you have ever had an allergic reaction to it.

Tell your doctor if you have ever had:

Bleomycin may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

You should not breastfeed while using bleomycin.

How is bleomycin given (Blenoxane)?

Bleomycin is given as an injection into a muscle or under the skin, or as an infusion into a vein. When treating pleural effusion, bleomycin is given through a chest tube.

A healthcare provider will give you this injection.

Bleomycin is usually given once or twice per week, depending on the condition being treated. When given through a chest tube, bleomycin is usually given only once.

To make sure this medicine is not causing harmful effects on your lungs, you may need to have chest X rays or other frequent lung function tests.

Your kidney function and liver function may also need to be checked.

If you need surgery, tell the surgeon ahead of time that you are being treated with bleomycin.

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What happens if I miss a dose (Blenoxane)?

Call your doctor for instructions if you miss an appointment for your bleomycin injection.

What happens if I overdose (Blenoxane)?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving bleomycin (Blenoxane)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect bleomycin (Blenoxane)?

Other drugs may affect bleomycin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information (Blenoxane)?

Your doctor or pharmacist can provide more information about bleomycin.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 1/21/2021

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