Brand Names: Bosulif
Generic Name: bosutinib
- What is bosutinib (Bosulif)?
- What are the possible side effects of bosutinib (Bosulif)?
- What is the most important information I should know about bosutinib (Bosulif)?
- What should I discuss with my healthcare provider before taking bosutinib (Bosulif)?
- How should I take bosutinib (Bosulif)?
- What happens if I miss a dose (Bosulif)?
- What happens if I overdose (Bosulif)?
- What should I avoid while taking bosutinib (Bosulif)?
- What other drugs will affect bosutinib (Bosulif)?
- Where can I get more information (Bosulif)?
What is bosutinib (Bosulif)?
Bosutinib is usually given after other treatments have failed.
Bosutinib may also be used for purposes not listed in this medication guide.
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What are the possible side effects of bosutinib (Bosulif)?
Stop using bosutinib and call your doctor at once if you have:
- severe or ongoing nausea, vomiting, stomach pain, or diarrhea;
- blood in your stools;
- urinating more or less than usual;
- swelling in your hands or feet, rapid weight gain;
- feeling light-headed or short of breath;
- low blood cell counts--fever, chills, tiredness, flu-like symptoms, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet;
- liver problems--upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
- swelling or fluid build-up in the lungs--anxiety, sweating, pain when you breathe, feeling short of breath while lying down, wheezing, gasping for breath, cough with foamy mucus, chest pain, fast or uneven heart rate.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
- headache, feeling tired;
- nausea, vomiting, diarrhea, stomach pain;
- fever, cough;
- rash; or
- pale skin, bruising or bleeding.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about bosutinib (Bosulif)?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What should I discuss with my healthcare provider before taking bosutinib (Bosulif)?
You should not use bosutinib if you are allergic to it.
Tell your doctor if you have ever had:
- liver disease;
- kidney disease;
- heart disease; or
- asthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder.
You may need to have a negative pregnancy test before starting this treatment.
Do not use bosutinib if you are pregnant. It could harm the unborn baby. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medicine, and for at least 1 month after your last dose.
You should not breastfeed while using this medicine, and for at least 1 month after your last dose.
How should I take bosutinib (Bosulif)?
Bosutinib is usually taken once per day. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Take with food.
Do not break or crush a bosutinib tablet. The medicine from a crushed or broken pill can be dangerous if it gets on your skin. If this occurs, wash your skin with soap and water. Ask your doctor or pharmacist how to safely handle and dispose of a broken tablet.
Bosutinib can lower your blood cell counts. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results.
You should not stop using bosutinib without your doctor's advice.
Store at room temperature away from moisture and heat.
What happens if I miss a dose (Bosulif)?
Take the medicine as soon as you can, but skip the missed dose if you are more than 12 hours late for the dose. Do not use two doses at one time.
What happens if I overdose (Bosulif)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking bosutinib (Bosulif)?
Grapefruit may interact with bosutinib and lead to unwanted side effects. Avoid the use of grapefruit products.
What other drugs will affect bosutinib (Bosulif)?
Some medicines can make bosutinib much less effective when taken at the same time. If you take an antacid or stomach acid reducer (Zantac, Prilosec, and others), take your bosutinib dose 2 hours before or 2 hours after you take the other medicine.
Tell your doctor about all your current medicines. Many drugs can affect bosutinib, especially:
- an antibiotic or antifungal medicine;
- an antidepressant;
- antiviral medicine to treat hepatitis C or HIV/AIDS;
- heart or blood pressure medicine; or
- other cancer medicines.
This list is not complete and many other drugs may affect bosutinib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Where can I get more information (Bosulif)?
Your pharmacist can provide more information about bosutinib.
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