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Medications and Drugs

Brand Names: Combigan

Generic Name: brimonidine and timolol ophthalmic (Pronunciation: bri MOE ni deen and TIM oh lol)

What is brimonidine and timolol ophthalmic (Combigan)?

Brimonidine reduces the amount of fluid in the eye, which decreases pressure inside the eye.

Timolol also reduces pressure inside the eye.

The combination of brimonidine and timolol ophthalmic (for the eyes) is used to treat glaucoma or ocular hypertension (high pressure inside the eye).

Brimonidine and timolol ophthalmic may also be used for other purposes not listed in this medication guide.

What are the possible side effects of brimonidine and timolol ophthalmic (Combigan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • severe swelling, itching, burning, redness, pain, or discomfort in or around your eye;
  • bronchospasm (wheezing, chest tightness, trouble breathing);
  • pounding heartbeats or fluttering in your chest;
  • slow heart rate, weak pulse, fainting, slow breathing (breathing may stop);
  • feeling like you might pass out;
  • numbness, tingling, or cold feeling in your hands or feet;
  • muscle weakness; or
  • confusion, hallucinations, unusual thoughts or behavior.

Less serious side effects may include:

  • mild burning, stinging, or itching of your eyes;
  • dry eyes, blurred vision;
  • mildly swollen or puffy eyes;
  • feeling like something is in your eye;
  • weakness, tired feeling;
  • cough, sore throat;
  • nausea, upset stomach;
  • headache;
  • drowsiness;
  • unusual or unpleasant taste in your mouth;
  • sensitivity to light;
  • dry nose;

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about brimonidine and timolol ophthalmic (Combigan)?

Do not use brimonidine and timolol ophthalmic if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

You should not use this medication if you are allergic to brimonidine (Alphagan) or timolol (Timoptic, Cosopt), or if you have certain conditions. Be sure your doctor knows if you have asthma, or severe chronic obstructive pulmonary disease (COPD), heart disease or heart failure, slow heartbeats, or a heart condition called "AV block."

Before using this medication, tell your doctor if you have diabetes, overactive thyroid, circulation problems, allergies, low blood pressure, myasthenia gravis, or a history of depression

Do not use this medication while you are wearing contact lenses. This medication may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using brimonidine and timolol ophthalmic before putting your contact lenses in.

Do not allow the dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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