cefuroxime (oral/injection) (Ceftin, Kefurox, Zinacef)

Brand Names: Ceftin, Kefurox, Zinacef, Zinacef ADD-Vantage, Zinacef TwistVial

Generic Name: cefuroxime (oral/injection)

What is cefuroxime?

Cefuroxime is a cephalosporin (SEF a low spor in) antibiotic that is used to treat bacterial infections of the ear, nose, throat, lungs, skin, bones, joints, bladder, or kidneys. Cefuroxime is also used to treat gonorrhea, meningitis, sepsis, or early Lyme disease.

Cefuroxime injection is sometimes given just before a surgery to prevent infection.

Cefuroxime may also be used for purposes not listed in this medication guide.

What are the possible side effects of cefuroxime?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
  • jaundice (yellowing of the skin or eyes);
  • fever, chills, headache, muscle pain;
  • light-headed feeling, like you might pass out;
  • problems with your hearing;
  • a seizure; or
  • kidney problems--little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about cefuroxime?

You should not use cefuroxime if you have ever had a severe allergic reaction to any type of cephalosporin antibiotic (Omnicef, Keflex, and others).

What should I discuss with my healthcare provider before using cefuroxime?

You should not use this medicine if you have an allergy to any type of penicillin, or if you are allergic to cefuroxime or any other cephalosporin antibiotic (cefdinir, cefalexin, Keflex, Omnicef, and others).

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

Some antibiotics can make birth control pills less effective. Ask your doctor about using a non-oral birth control to prevent pregnancy. This includes injections, implants, skin patches, vaginal rings, condom, diaphragm, cervical cap, or contraceptive sponge.

Cefuroxime is not approved for use by anyone younger than 3 months old.

How should I use cefuroxime?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Cefuroxime oral is taken by mouth.

Cefuroxime oral may be given as a single dose to treat gonorrhea. For most other infections, cefuroxime oral is usually given for 7 to 10 days, or for 20 days to treat early Lyme disease. Follow your doctor's dosing instructions very carefully.

Swallow the tablet whole and do not crush, chew, or break it. You may take cefuroxime oral with or without food.

Tell your doctor if a child taking cefuroxime oral cannot swallow a tablet whole.

Cefuroxime injection is injected into a muscle, or as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with cefuroxime injection. Ask your doctor or pharmacist if you don't understand all instructions.

Prepare an injection only when you are ready to give it. Do not use if the medicine lhas changed colors or has particles in it. Call your pharmacist for new medicine.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Cefuroxime will not treat a viral infection such as the flu or a common cold.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using cefuroxime.

Store cefuroxime oral at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Cefuroxime injection is a powder that must be mixed with a diluent before you inject the medicine. If the cefuroxime injection is frozen when you receive it, thaw the medicine at room temperature (do not use heat).

After thawing, you may store the cefuroxime injection at room temperature for up to 24 hours, or in a refrigerator for up to 7 days. Do not refreeze the medicine once it has been thawed.

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What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Call your doctor for instructions if you miss a cefuroxime injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include seizure.

What should I avoid while using cefuroxime?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

What other drugs will affect cefuroxime?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect cefuroxime, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about cefuroxime.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 7/12/2021

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