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Medications and Drugs

Brand Names: aeroHist, AlleRx DF Dose Pack, Ryneze

Generic Name: chlorpheniramine and methscopolamine (Pronunciation: klor fen EER uh meen and meth sko POL uh meen)

What is chlorpheniramine and methscopolamine (aeroHist, AlleRx DF Dose Pack, Ryneze)?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Methscopolamine reduces the secretions of certain organs in the body.

The combination of chlorpheniramine and methscopolamine is used to treat symptoms of the common cold or seasonal allergies, including sneezing, runny or stuffy nose, and itchy, watery eyes.

Chlorpheniramine and methscopolamine may also be used for purposes other than those listed in this medication guide.


oblong, blue, imprinted with AERO

What are the possible side effects of chlorpheniramine and methscopolamine (aeroHist, AlleRx DF Dose Pack, Ryneze)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using chlorpheniramine and methscopolamine and call your doctor at once if you have any of these serious side effects:

  • problems with balance or coordination;
  • severe drowsiness, feeling light-headed, fainting;
  • extreme thirst and hot, dry skin;
  • breathing problems;
  • easy bruising or bleeding, unusual weakness;
  • fever, chills, body aches, flu symptoms;
  • fast or uneven heart beats;
  • tight feeling in your chest;
  • seizure (convulsions);
  • hallucinations (seeing things that are not there); or
  • tremors.

Continue using this medication and talk with your doctor if you have any of these less serious side effects:

  • dry mouth, stomach pain, changes in appetite;
  • drowsiness, dizziness, weakness, headache;
  • dry eyes, blurred vision;
  • painful or difficult urination;
  • increased sweating;
  • skin rash; or
  • feeling nervous or excited (especially in children).

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about chlorpheniramine and methscopolamine (aeroHist, AlleRx DF Dose Pack, Ryneze)?

Do not use chlorpheniramine and methscopolamine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Dangerous side effects may occur if you take chlorpheniramine and methscopolamine before the MAO inhibitor has cleared from your body.

Do not use this medication if you are allergic to chlorpheniramine or methscopolamine, or if you have severe high blood pressure or coronary artery disease, narrow-angle glaucoma, a stomach ulcer, or if you are unable to urinate.

Do not use this medication during an asthma attack.

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid becoming overheated in hot weather. Chlorpheniramine and methscopolamine increases the risk of heat stroke because it causes decreased sweating and can make you more sensitive to sunlight.

Avoid drinking alcohol. It can increase some of the side effects of chlorpheniramine and methscopolamine.

Avoid using other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety), or medicines that may cause restlessness (such as caffeine, stimulants, diet pills, and decongestants contained in over-the-counter cold medicines). They can add to the side effects of chlorpheniramine and methscopolamine.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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