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Medications and Drugs

Brand Names: Diabinese

Generic Name: chlorpropamide (Pronunciation: klor PROE pa mide)

What is chlorpropamide (Diabinese)?

Chlorpropamide is an oral diabetes medicine that helps control blood sugar levels. This medication helps your pancreas produce insulin.

Chlorpropamide is used together with diet and exercise to treat type 2 diabetes. Other diabetes medicines are sometimes used in combination with chlorpropamide if needed.

Chlorpropamide should not be used by itself to treat type 1 diabetes.

Chlorpropamide may also be used for purposes not listed in this medication guide.

Chloropropamide 250 mg-MYL

round, green, imprinted with MYLAN 210, 250

Chlorpropamide 100 mg-MYL

round, green, imprinted with 100, MYLAN 197

What are the possible side effects of chlorpropamide (Diabinese)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Hypoglycemia, or low blood sugar, is the most common side effect of chlorpropamide. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). Carry hard candy or glucose tablets with you in case you have low blood sugar.

Stop taking chlorpropamide and call your doctor at once if you have a serious side effect such as:

  • easy bruising or bleeding, unusual weakness;
  • pale skin, fever, confusion;
  • trouble concentrating, memory problems, feeling unsteady, hallucinations;
  • feeling light-headed, fainting;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • throbbing headache, sweating, severe nausea, trouble breathing, fast or pounding heartbeats, blurred vision, spinning sensation; or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • mild nausea, vomiting, diarrhea;
  • mild hunger; or
  • mild skin rash, redness, or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about chlorpropamide (Diabinese)?

Do not use this medication if you are allergic to chlorpropamide, or if you are in a state of diabetic ketoacidosis. Call your doctor for treatment with insulin.

Before taking chlorpropamide, tell your doctor if you have kidney or liver disease, a disorder of your pituitary or adrenal glands, a history of heart disease, or if you are malnourished.

Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with chlorpropamide.

Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.

Signs of blood sugar that is too high (hyperglycemia) may include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss. Your blood sugar will need to be checked often, and you may need to adjust your chlorpropamide dose.

Chlorpropamide is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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