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cyclophosphamide (oral/injection)

Generic Name: cyclophosphamide (oral/injection)

What is cyclophosphamide?

Cyclophosphamide is used to treat several types of cancer.

Cyclophosphamide is also used to treat minimal change nephrotic syndrome (kidney disease) in children who cannot use other treatments or when other treatments have failed.

Cyclophosphamide may also be used for purposes not listed in this medication guide.

What are the possible side effects of cyclophosphamide?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • new worsening cough, shortness of breath, trouble breathing while lying down;
  • a light-headed feeling, like you might pass out;
  • pink or red urine, pain or burning when you urinate;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • any wound that will not heal;
  • heart problems--swelling, rapid weight gain, pounding heartbeats or fluttering in your chest;
  • liver problems--loss of appetite, stomach pain (upper right side), bloating, dark urine, jaundice (yellowing of the skin or eyes);
  • low sodium level--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady; or
  • low blood cell counts--fever, chills, tiredness, blisters or ulcers in your mouth, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about cyclophosphamide?

You should not use cyclophosphamide if you have a bladder obstruction or other urination problems.

What should I discuss with my healthcare provider before using cyclophosphamide?

You should not use cyclophosphamide if you are allergic to it, or if you have:

  • a bladder obstruction.

Tell your doctor if you have ever had:

  • a weak immune system (caused by disease or by using certain medicines);
  • an active or chronic infection (including a bladder infection);
  • bladder problems;
  • kidney disease (or if you are on dialysis);
  • lung disease;
  • heart disease;
  • liver disease; or
  • if you are receiving other cancer treatments or radiation.

Using cyclophosphamide may increase your risk of developing other types of cancer such as bladder cancer, thyroid cancer, or leukemia. Talk with your doctor about your specific risk.

Cyclophosphamide can harm an unborn baby if the mother or the father is using this medicine.

  • If you are a woman, do not use cyclophosphamide if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 year after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using cyclophosphamide.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because cyclophosphamide can harm an unborn baby.

Cyclophosphamide may cause you to stop having menstrual periods. Your periods should return to normal within a few months after you stop using cyclophosphamide. However, older women may have early menopause due to this effect. Talk to your doctor about this risk.

You should not breastfeed while you are using this medicine.

How is cyclophosphamide given?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Cyclophosphamide oral is taken by mouth.

Cyclophosphamide injection is given as an infusion into a vein. A healthcare provider will give you this injection.

Drink plenty of liquids each day to prevent harmful effects on your bladder.

Cyclophosphamide affects your immune system. You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis.

Cyclophosphamide can lower your blood cell counts. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results.

If you need surgery, tell the surgeon ahead of time that you are using cyclophosphamide. You may need to stop using the medicine for a short time.

Ask your doctor or pharmacist how to safely handle this medicine. Cyclophosphamide can be harmful if it gets on your skin. If this occurs, wash thoroughly with soap and water.

Store at room temperature away from moisture and heat.

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What happens if I miss a dose?

For cyclophosphamide oral: Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Call your doctor for instructions if you miss a dose of cyclophosphamide injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include mouth sores, trouble breathing, fast heartbeats, rapid weight gain, stomach pain, or yellowing of your skin or eyes.

What should I avoid while using cyclophosphamide?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

What other drugs will affect cyclophosphamide?

Tell your doctor about all your current medicines. Many drugs can affect cyclophosphamide, especially:

This list is not complete and many other drugs may affect cyclophosphamide. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your doctor or pharmacist can provide more information about cyclophosphamide.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 1/21/2021

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