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daptomycin (Cubicin, Cubicin RF)

Brand Names: Cubicin, Cubicin RF

Generic Name: daptomycin

What is daptomycin (Cubicin, Cubicin RF)?

Daptomycin is an antibiotic that is used to treat bacterial infections of the skin and underlying tissues, and infections that have entered the bloodstream.

Daptomycin is used for complicated infections, including MRSA or "super bug" infections. MRSA stands for methicillin-resistant Staphylococcus aureus.

Daptomycin may also be used for purposes not listed in this medication guide.

What are the possible side effects of daptomycin (Cubicin, Cubicin RF)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
  • fever, flu symptoms, mouth and throat ulcers, rapid heart rate, shallow breathing;
  • pain or burning when you urinate;
  • numbness, tingling, or burning pain in your hands or feet;
  • new or worsening cough, fever, trouble breathing; or
  • unexplained muscle pain, tenderness, or weakness.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about daptomycin (Cubicin, Cubicin RF)?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What should I discuss with my healthcare provider before using daptomycin (Cubicin, Cubicin RF)?

You should not use daptomycin if you are allergic to it.

Tell your doctor if you have ever had:

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How should I use daptomycin (Cubicin, Cubicin RF)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Daptomycin is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Do not use daptomycin if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.

Daptomycin is sometimes given slowly, and the infusion can take 30 to 60 minutes to complete.

Daptomycin must be mixed with a liquid (diluent) before using it. Prepare your injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

You may need frequent blood and urine tests.

This medicine may cause false results with certain medical tests. Tell any doctor who treats you that you are using daptomycin.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Some infections must be treated for up to 6 weeks. Skipping doses can increase your risk of infection that is resistant to medication. Daptomycin will not treat a viral infection such as the flu or a common cold.

Store daptomycin in the refrigerator. Do not freeze. After mixing daptomycin with a diluent, store in the refrigerator and use it within 48 hours.

You may also store mixed daptomycin for up to 12 hours at room temperature.

Each vial (bottle) is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose (Cubicin, Cubicin RF)?

Call your doctor for instructions if you miss a dose.

What happens if I overdose (Cubicin, Cubicin RF)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using daptomycin (Cubicin, Cubicin RF)?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

What other drugs will affect daptomycin (Cubicin, Cubicin RF)?

Tell your doctor about all your other medicines, especially a "statin" cholesterol medicine such as:

This list is not complete. Other drugs may affect daptomycin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Cubicin, Cubicin RF)?

Your pharmacist can provide more information about daptomycin.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 12/19/2018

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