dasiglucagon (Zegalogue Autoinjector, Zegalogue Prefilled Syringe)

Brand Names: Zegalogue Autoinjector, Zegalogue Prefilled Syringe

Generic Name: dasiglucagon

What is dasiglucagon (Zegalogue Autoinjector, Zegalogue Prefilled Syringe)?

Dasiglucagon is used to treat very low blood sugar (severe hypoglycemia) in adults and children at least 6 years old.

Dasiglucagon may also be used for purposes not listed in this medication guide.

What are the possible side effects of dasiglucagon (Zegalogue Autoinjector, Zegalogue Prefilled Syringe)?

Get emergency medical help if you have signs of an allergic reaction: hives; feeling light-headed; difficulty breathing; fast or slow heartbeat; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about dasiglucagon (Zegalogue Autoinjector, Zegalogue Prefilled Syringe)?

Be sure you and your caregivers know how to give a dasiglucagon injection before you need to use it. Hypoglycemia should be treated as quickly as possible. Having low blood sugar for too long can cause seizure, coma, or death.

What should I discuss with my healthcare provider before using dasiglucagon (Zegalogue Autoinjector, Zegalogue Prefilled Syringe)?

You should not use dasiglucagon if you are allergic to it, or if you have:

  • a tumor of the pancreas (insulinoma); or
  • a tumor of the adrenal gland (pheochromocytoma).

Tell your doctor if you have:

  • any tumor of the pancreas;
  • chronic low blood sugar;
  • adrenal gland problems;
  • a latex allergy; or
  • if you have not recently eaten on a regular basis.

Do not give this medicine to a child without medical advice.

Tell your doctor if you are pregnant or breastfeeding.

Dasiglucagon is not expected to harm an unborn baby, but quickly treating hypoglycemia would outweigh any risks posed by using dasiglucagon.

In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.

How should I use dasiglucagon (Zegalogue Autoinjector, Zegalogue Prefilled Syringe)?

Hypoglycemia should be treated as quickly as possible. Having low blood sugar for too long can cause seizure, coma, or death.

Dasiglucagon is injected under the skin. You will be shown how to use emergency dasiglucagon injections for severe hypoglycemia. Call your doctor after each time you use a dasiglucagon injection.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Prepare an injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Be sure you and your caregivers know how to give a dasiglucagon injection before you need to use it. The correct dose for a child is the same as that for an adult dose. Follow your doctor's dosing instructions very carefully.

After the injection, you should eat a fast-acting source of sugar (fruit juice, glucose gel, hard candy, raisins, or non-diet soda) and then eat a snack or small meal such as cheese or peanut butter and crackers.

If you are a caregiver, get emergency medical help after giving a dasiglucagon injection. If the patient does not improve within 15 minutes, you may need to give a second injection.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

To keep from having severe hypoglycemia, follow your diet, medication, and exercise routines very closely.

Store in the refrigerator, away from the cooling element. Do not freeze.

You may also store dasiglucagon at room temperature but you must use the medicine within 12 months or throw it away. Protect from light by storing the medicine in the protective case. Do not put the medicine back into a refrigerator after storing it at room temperature.

Do not use this medicine after the expiration date on the label has passed.


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What happens if I miss a dose (Zegalogue Autoinjector, Zegalogue Prefilled Syringe)?

Since dasiglucagon is used as needed, it does not have a daily dosing schedule.

Call your doctor promptly if symptoms do not improve after using dasiglucagon.

What happens if I overdose (Zegalogue Autoinjector, Zegalogue Prefilled Syringe)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, fast heartbeats, or high blood pressure.

What should I avoid while using dasiglucagon (Zegalogue Autoinjector, Zegalogue Prefilled Syringe)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect dasiglucagon (Zegalogue Autoinjector, Zegalogue Prefilled Syringe)?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect dasiglucagon, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Zegalogue Autoinjector, Zegalogue Prefilled Syringe)?

Your pharmacist can provide more information about dasiglucagon.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 3/17/2022

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