demeclocycline (Declomycin)

Brand Names: Declomycin

Generic Name: demeclocycline

What is demeclocycline (Declomycin)?

Demeclocycline is a tetracycline antibiotic that is used to treat many different bacterial infections, such as urinary tract infections, lung infections, intestinal infections, acne, gonorrhea, chlamydia, Rocky Mountain spotted fever, and others.

Demeclocycline may also be used for purposes not listed in this medication guide.

What are the possible side effects of demeclocycline (Declomycin)?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
  • new or worsening cough, fever, trouble breathing;
  • painful swallowing, vomiting blood (avoid lying down right after taking demeclocycline);
  • kidney problems--swelling, urinating less, feeling tired or short of breath;
  • low blood cell counts--fever, chills, tiredness, confusion or weakness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath;
  • increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; or
  • signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), tiredness, nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • nausea, vomiting, diarrhea, loss of appetite;
  • darkened skin color;
  • swollen tongue, trouble swallowing; or
  • vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about demeclocycline (Declomycin)?

Using demeclocycline during pregnancy may cause bone growth problems in the unborn baby, or permanent tooth discoloration later in life.

Children younger than 8 years old should use demeclocycline only for infections that cannot be treated with a safer antibiotic.

What should I discuss with my healthcare provider before taking demeclocycline (Declomycin)?

You should not use this medicine if you are allergic to demeclocycline or similar antibiotics such as doxycycline, minocycline, or tetracycline.

Tell your doctor if you have ever had:

If you are using demeclocycline to treat gonorrhea, your doctor may test you to make sure you do not also have syphilis, another sexually transmitted disease.

Do not use if you are pregnant. Taking demeclocycline during the second or third trimester of pregnancy may cause bone growth problems in the unborn baby, or permanent tooth discoloration later in life.

Demeclocycline can make birth control pills less effective. Ask your doctor about other birth control options such as an injection, implant, skin patch, vaginal ring, condom, diaphragm, cervical cap, or contraceptive sponge.

Demeclocycline can pass into breast milk and may affect bone and tooth development in a nursing infant. Do not breastfeed while you are taking doxycycline.

Children younger than 8 years old should use demeclocycline only for infections that cannot be treated with a safer antibiotic. Demeclocycline can affect a child's growth or cause permanent yellowing or graying of the teeth.

How should I take demeclocycline (Declomycin)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take on an empty stomach, at least 1 hour before or 2 hours after a meal.

Keep using this medicine even if your symptoms quickly improve. Skipping doses could make your infection resistant to medication. Demeclocycline will not treat a viral infection (flu or a common cold).

Demeclocycline is usually given for up to 2 days after symptoms and fever have cleared.

Do not share this medicine with another person, even if they have the same symptoms you have.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

Throw away any unused medicine after the expiration date on the label has passed.


Bacterial Infections 101: Types, Symptoms, and Treatments See Slideshow

What happens if I miss a dose (Declomycin)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose (Declomycin)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking demeclocycline (Declomycin)?

Avoid taking anti-diarrhea medicine without first asking your doctor. Diarrhea may be a sign of a new infection.

Demeclocycline could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Avoid taking iron supplements, multivitamins, calcium supplements, antacids, or laxatives.

Do not take with milk or other dairy products unless your doctor tells you to.

What other drugs will affect demeclocycline (Declomycin)?

Tell your doctor about all your other medicines, especially a blood thinner such as warfarin, Coumadin, or Jantoven.

Other drugs may affect demeclocycline, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Where can I get more information (Declomycin)?

Your pharmacist can provide more information about demeclocycline.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 10/12/2022

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