diazepam nasal (Valtoco)

Brand Names: Valtoco

Generic Name: diazepam nasal

What is diazepam nasal (Valtoco)?

Diazepam nasal is a benzodiazepine (ben-zoe-dye-AZE-eh-peen) that is used to treat seizure clusters in adults and children at least 6 years old.

Diazepam nasal may also be used for purposes not listed in this medication guide.

What are the possible side effects of diazepam nasal (Valtoco)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Diazepam can slow or stop your breathing, especially if you have recently used an opioid medication, alcohol, or other drugs that can slow your breathing. A person caring for you should seek emergency medical attention if you have weak or shallow breathing, if you are hard to wake up, or if you stop breathing.

Call your doctor at once if the person receiving this medication has:

The sedative effects of diazepam may last longer in older adults. Accidental falls are common in elderly patients who use benzodiazepines. Use caution to avoid falling or accidental injury while you are using diazepam nasal.

Common side effects may include:

  • drowsiness;
  • headache; or
  • discomfort in your nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about diazepam nasal (Valtoco)?

Diazepam can slow or stop your breathing, especially if you have recently used an opioid medication, alcohol, or other drugs that can slow your breathing.

MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.

Some people have thoughts about suicide while using diazepam nasal. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

What should I discuss with my healthcare provider before using diazepam nasal (Valtoco)?

You should not use this medicine if you are allergic to diazepam (Valium), or if you have:

Diazepam nasal is not approved for use by anyone younger than 6 years old.

Tell your doctor if you have ever had:

Some people have thoughts about suicide while taking diazepam. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Do not start or stop using seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of diazepam nasal on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

How should I use diazepam nasal (Valtoco)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Never use diazepam in larger amounts, or for longer than prescribed.

Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

Diazepam is a nasal spray that comes in a ready-to-use bottle. Each bottle is for one use only. Use only the number of sprays your doctor has prescribed.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Be sure a responsible family member or caregiver knows where you keep this medicine and how to give it to you.

After giving diazepam nasal to another person:

  • note the time the diazepam dose was given;
  • keep the person lying on his or her side;
  • stay with the person and watch for changes in his or her seizures.

Seek emergency medical help if the person's seizure seems different or last longer than other seizures, or if the person has slow breathing, blue colored lips, or is hard to wake up.

If needed, a second dose of diazepam nasal may be given at least 4 hours after the first dose. Do not give a second dose if the person has extreme drowsiness or very slow breathing.

Diazepam doses are based on weight. Your dose needs may change if you gain or lose weight.

Do not use more than 2 doses to treat a single seizure cluster episode.

Do not use diazepam nasal for more than 1 seizure cluster every 5 days. Do not use for more than 5 seizure clusters in 1 month.

If you stop using diazepam nasal suddenly after long-term use, you could have unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture, heat, and light. Do not freeze.


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What happens if I miss a dose (Valtoco)?

Since diazepam nasal is used when needed, it does not have a daily dosing schedule. Call your doctor if your symptoms do not improve after using this medicine.

Keep this medicine with you at all times in case you need it to control seizure clusters.

What happens if I overdose (Valtoco)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include drowsiness, confusion, or loss of consciousness.

What should I avoid while using diazepam nasal (Valtoco)?

Avoid drinking alcohol. Dangerous side effects could occur.

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

What other drugs will affect diazepam nasal (Valtoco)?

Using diazepam nasal with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, opioid medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect diazepam nasal, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information (Valtoco)?

Your pharmacist can provide more information about diazepam nasal.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 3/17/2022

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