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Medications and Drugs

Brand Names: Durezol

Generic Name: difluprednate ophthalmic (Pronunciation: DYE floo PRED nate off THAL mik)

What is difluprednate ophthalmic (Durezol)?

Difluprednate is a steroid medicine. It prevents the release of substances in the body that cause inflammation.

Difluprednate ophthalmic (for the eye) is used to treat eye pain and inflammation caused by surgery.

Difluprednate ophthalmic is also used to treat anterior uveitis, inflammation that affects the front part of the eye.

Difluprednate ophthalmic may also be used for purposes not listed in this medication guide.

What are the possible side effects of difluprednate ophthalmic (Durezol)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • pain behind your eyes, sudden vision changes, severe headache;
  • sudden eye redness, itching, or other irritation;
  • slow healing after your eye surgery;
  • signs of new eye infection, such as swelling, draining, or crusting of your eyes;
  • eye pain, tunnel vision, or seeing halos around lights; or
  • changes in the color or appearance of your iris (the colored part of your eye).

Less serious side effects may include:

  • mild headache;
  • blurred vision;
  • mild burning, stinging, or itching of your eyes;
  • dry or watery eyes;
  • feeling like something is in your eye; or
  • increased sensitivity of your eyes to light.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about difluprednate ophthalmic (Durezol)?

You should not use this medication if you are allergic to difluprednate, or if you have untreated glaucoma, any type of eye infection (including herpes), or an untreated infection in your eyes or elsewhere (including chickenpox).

Before using difluprednate ophthalmic, tell your doctor if you have glaucoma or cataracts.

Do not allow the tip of the dropper to touch any surface, including your eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Do not use difluprednate ophthalmic while you are wearing regular contact lenses. Wait at least 10 minutes after using difluprednate before putting in the lenses. Do not wear any contact lens that has not been approved by your doctor.

Talk with your doctor if your symptoms do not improve after 2 days of treatment. Do not stop using difluprednate ophthalmic without first talking to your doctor. You may need to use less and less before you stop the medication completely.

This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Call your doctor at once if you have sudden eye irritation or pain, severe eye redness or itching, pain behind your eyes, sudden vision changes, severe headache, slow healing after your eye surgery, signs of new eye infection (swelling, draining, crusting), tunnel vision, seeing halos around lights, or changes in the color or appearance of your iris (the colored part of your eye).

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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