dipyridamole (oral/injection) (Persantine, Persantine IV)

Brand Names: Persantine, Persantine IV

Generic Name: dipyridamole (oral/injection)

What is dipyridamole (Persantine, Persantine IV)?

Dipyridamole oral is used to prevent blood clots after heart valve replacement surgery.

Dipyridamole injection is given as part of a test that shows how well your heart is pumping blood. This is sometimes called a "stress test."

Dipyridamole may also be used for other purposes not listed in this medication guide.

What are the possible side effects of dipyridamole (Persantine, Persantine IV)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

Older adults may be more likely to feel light-headed while taking dipyridamole.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about dipyridamole (Persantine, Persantine IV)?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

`What should I discuss with my healthcare provider before taking dipyridamole (Persantine, Persantine IV)?

You should not use dipyridamole if you are allergic to it.

Tell your doctor if you have ever had:

Before you have a stress test with dipyridamole injection: Tell your doctor if you already take dipyridamole by mouth, or if you take an asthma medicine called theophylline.

Tell your doctor if you are pregnant or breastfeeding.

Dipyridamole oral is not approved for use by anyone younger than 12 years old. Dipyridamole injection is used only in adults.

How should I take dipyridamole (Persantine, Persantine IV)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Dipyridamole oral is taken by mouth, sometimes with other medications to prevent blood clots. Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice.

You may need frequent medical tests.

Store at room temperature away from moisture and heat.

Dipyridamole injection is given as an infusion into a vein. A healthcare provider will give you dipyridamole and other injected medicines during your stress test.

If you need a stress test while you are taking dipyridamole by mouth, you may need to stop taking it 48 hours before your stress test. Follow all instructions about how to prepare for this test.


In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer

What happens if I miss a dose (Persantine, Persantine IV)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Dipyridamole injection is used as a single dose and does not have a daily dosing schedule.

What happens if I overdose (Persantine, Persantine IV)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include flushing (warmth, redness, or tingly feeling), restless feeling, sweating, weakness, or fainting.

What should I avoid while taking dipyridamole (Persantine, Persantine IV)?

Ask a doctor or pharmacist before using aspirin or any medicines for pain, fever, swelling, or cold/flu symptoms

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

For 24 hours before a stress test: Your doctor may tell you to avoid certain foods or beverages that contain caffeine (such as coffee, tea, energy drinks, chocolate). Follow these instructions carefully to avoid your test having to be postponed or cancelled.

What other drugs will affect dipyridamole (Persantine, Persantine IV)?

Tell your doctor about all your other medicines, especially:

  • medicine to treat Parkinson's disease; or
  • medicine to treat dementia or symptoms of Alzheimer's disease.

This list is not complete. Other drugs may affect dipyridamole, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Persantine, Persantine IV)?

Your pharmacist can provide more information about dipyridamole.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 10/12/2022

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