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Medications and Drugs

Brand Names: Ogen 0.625, Ogen 1.25, Ogen 2.5

Generic Name: estropipate (Pronunciation: ES troe PIP ate)

What is estropipate (Ogen 0.625, Ogen 1.25, Ogen 2.5)?

Estropipate is a form of estrogen. Estrogen is a female sex hormone necessary for many processes in the body.

Estropipate is used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. It is also used to prevent osteoporosis.

Estropipate may also be used for purposes other than those listed in this medication guide.

Estropipate 0.75 mg-BAR

round, yellow, imprinted with barr, 555 727

Estropipate 0.75 mg-MYL

round, yellow, imprinted with M E7

Estropipate 0.75 mg-WAT

round, yellow, imprinted with WATSON 414

Estropipate 1.5 mg-BAR

round, peach, imprinted with barr, 555 728

Estropipate 1.5 mg-MYL

round, peach, imprinted with M E8

Estropipate 1.5 mg-WAT

round, orange, imprinted with WATSON, 415

Estropipate 3 mg-BAR

round, blue, imprinted with barr, 555 729

Estropipate 3 mg-WAT

round, blue, imprinted with WATSON 416

Ogen 0.625 mg-PFI

oval, yellow, imprinted with U 3772

Ogen 1.25 mg-PFI

oval, orange, imprinted with U 1773

Ogen 2.5 mg-PFI

oval, blue, imprinted with U 3774

Ortho-Est 0.75 mg

diamond, white, imprinted with ORTHO 1801

Ortho-Est 1.5 mg

diamond, lavender, imprinted with ORTHO 1800

What are the possible side effects of estropipate (Ogen 0.625, Ogen 1.25, Ogen 2.5)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden headache, confusion, problems with vision, speech, or balance;
  • pain or swelling in your lower leg;
  • abnormal vaginal bleeding;
  • pain, swelling, or tenderness in your stomach;
  • jaundice (yellowing of the skin or eyes); or
  • a lump in your breast.

Other less serious side effects are more likely to occur, such as:

  • nausea, vomiting, loss of appetite;
  • swollen breasts;
  • acne or skin color changes;
  • decreased sex drive, impotence, or difficulty having an orgasm;
  • migraine headaches or dizziness;
  • vaginal pain, dryness, or discomfort;
  • swelling of your ankles or feet;
  • depression; or
  • changes in your menstrual periods, break-through bleeding.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about estropipate (Ogen 0.625, Ogen 1.25, Ogen 2.5)?

Do not use this medication if you have any of the following conditions: a history of stroke or blood clot, circulation problems, a hormone-related cancer such as breast or uterine cancer, or abnormal vaginal bleeding.

This medication can cause birth defects in an unborn baby. Do not use if you are pregnant. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Estropipate increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estropipate may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estropipate.

Long-term estropipate treatment may increase your risk of breast cancer, heart attack, or stroke. Talk with your doctor about your individual risks before using estropipate long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using estropipate.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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