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Medications and Drugs

Brand Names: Tri-Luma

Generic Name: fluocinolone, hydroquinone, and tretinoin topical (Pronunciation: FLOO oh SIN oh lone, HYE droe KWIN one, TRET in oin)

What is fluocinolone, hydroquinone, and tretinoin topical (Tri-Luma)?

Fluocinolone is a steroid. It reduces inflammation or swelling.

Hydroquinone topical is a skin bleaching agent.

Tretinoin topical is a form of vitamin A. It helps the skin to renew itself more quickly.

The combination of fluocinolone, hydroquinone, and tretinoin topical is used to treat melasma (dark skin patches) of the face.

Fluocinolone, hydroquinone, and tretinoin topical may also be used for other purposes not listed in this medication guide.

What are the possible side effects of fluocinolone, hydroquinone, and tretinoin topical (Tri-Luma)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor if you have any of these serious side effects:

  • darkening of the treated skin;
  • severe skin irritation, blistering, oozing, scaling, or crusting;
  • severe burning or swelling of the skin; or
  • irritation of your eyes, nose, or mouth.

Less serious side effects may include:

  • mild redness, burning, stinging, tingling, itching, swelling, dryness, or peeling of your skin;
  • rash;
  • acne;
  • skin bumps or blisters; or
  • more noticeable red lines or blood vessels showing through your skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about fluocinolone, hydroquinone, and tretinoin topical (Tri-Luma)?

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). This medication can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

Avoid getting this medication in your mouth, eyes, or nose, and avoid applying it to your lips or in the creases of your nose. If it does get into any of these areas, rinse with water. Do not use the medication on sunburned, windburned, dry, chapped, irritated, or broken skin. Wait until these areas have healed.

Your skin may be more sensitive to weather extremes such as cold and wind. Protect your skin with clothing and use a moisturizing cream or lotion as needed.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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