fluorouracil (injection) (Adrucil)

Brand Names: Adrucil

Generic Name: fluorouracil (injection)

What is fluorouracil (Adrucil)?

Fluorouracil is used to treat cancer of the colon, rectum, breast, stomach, or pancreas.

Fluorouracil is often given in combination chemotherapy with other cancer drugs.

Fluorouracil may also be used for purposes not listed in this medication guide.

What are the possible side effects of fluorouracil (Adrucil)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fever (take your temperature each day while receiving fluorouracil);
  • severe or ongoing diarrhea;
  • vision problems;
  • confusion, problems with balance or muscle movement;
  • painful mouth sores, red or swollen gums, trouble swallowing, talking, or eating;
  • bone marrow suppression--dizziness, pale lips or fingernail beds, fast heart rate, getting easily tired or short of breath;
  • "hand and foot syndrome"--pain, blisters, bleeding, or severe rash on the palms of your hands or the soles of your feet;
  • heart problems--chest pain or pressure, pain spreading to your jaw or shoulder, irregular heartbeats, nausea, sweating, feeling dizzy or short of breath.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • diarrhea;
  • mouth sores;
  • heart problems; or
  • bone marrow suppression.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about fluorouracil (Adrucil)?

Before using fluorouracil tell your doctor about all your medical conditions or allergies, all medicines you use, and if you are pregnant or breastfeeding.

What should I discuss with my healthcare provider before receiving fluorouracil (Adrucil)?

Tell your doctor if you have ever had:

  • a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency;
  • heart problems; or
  • bone marrow depression.

Both men and women using this medicine should use effective birth control to prevent pregnancy. Fluorouracil can harm an unborn baby if the mother or father is using this medicine.

Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using fluorouracil.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because fluorouracil can harm an unborn baby.

You should not breastfeed while using this medicine.

How is fluorouracil given (Adrucil)?

Fluorouracil is given as an infusion into a vein. A healthcare provider will give you this injection.

You may receive your first dose in a hospital or clinic setting to quickly treat any serious side effects.

Fluorouracil is often given in a treatment cycle, and you may need to use the medicine only on certain days of each cycle. Fluorouracil is sometimes given in a continuous infusion over 24 to 46 hours.

How often you need fluorouracil injections will depend on many factors, including side effects and how your body responds to the medicine. Your doctor will determine how long to treat you with this medicine.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when fluorouracil is injected.

Fluorouracil can increase your risk of bleeding or infection. You will need frequent medical tests. Your cancer treatments may be delayed based on the results of these tests.


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What happens if I miss a dose (Adrucil)?

Call your doctor for instructions if you miss an appointment for your fluorouracil injection.

What happens if I overdose (Adrucil)?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving fluorouracil (Adrucil)?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

What other drugs will affect fluorouracil (Adrucil)?

If you take a blood thinner (warfarin, Coumadin, Jantoven), you may need to have more frequent "INR" or prothrombin time tests.

Other drugs may affect fluorouracil, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information (Adrucil)?

Your doctor or pharmacist can provide more information about fluorouracil.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 10/12/2022

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