fluphenazine (oral/injection) (Permitil, Prolixin, Prolixin Decanoate)

Brand Names: Permitil, Prolixin, Prolixin Decanoate

Generic Name: fluphenazine (oral/injection)

What is fluphenazine (Permitil, Prolixin, Prolixin Decanoate)?

Fluphenazine is a phenothiazine (FEEN-oh-THYE-a-zeen) antipsychotic medicine that is used to treat psychotic disorders such as schizophrenia.

Fluphenazine may also be used for purposes not listed in this medication guide.

What are the possible side effects of fluphenazine (Permitil, Prolixin, Prolixin Decanoate)?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

High doses or long-term use of fluphenazine can cause a serious movement disorder that may not be reversible. The longer you use fluphenazine, the more likely you are to develop this disorder, especially if you are an older adult.

Call your doctor at once if you have:

  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
  • extreme drowsiness or light-headed feeling (like you might pass out);
  • strange dreams, or if you feel restless or excited;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • painful or difficult urination;
  • severe constipation, stomach pain, bloating;
  • jaundice (yellowing of the skin or eyes);
  • a seizure; or
  • low white blood cell counts--fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing, feeling light-headed.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about fluphenazine (Permitil, Prolixin, Prolixin Decanoate)?

You should not use fluphenazine if you have liver disease, brain damage, severe depression, a blood cell disorder, or if you are also using large amounts of alcohol or medicines that make you sleepy.

Fluphenazine is not approved for use in older adults with dementia-related psychosis.

Call your doctor at once if you have uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects.

What should I discuss with my healthcare provider before using fluphenazine (Permitil, Prolixin, Prolixin Decanoate)?

You should not use this medicine if you are allergic to fluphenazine or other phenothiazines (chlorpromazine, perphenazine, prochlorperazine, promethazine, thioridazine, trifluoperazine), or if you have:

  • liver disease;
  • brain damage;
  • severe depression; or
  • a blood cell disorder (such as low platelets or low red or white blood cell counts).

Do not use fluphenazine if you have recently used large amounts of alcohol or medicine that makes you sleepy.

Fluphenazine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

Tell your doctor if you have ever had:

Tell your doctor if you will be exposed to extreme heat or cold, or to insecticide poisons while you are using fluphenazine.

Fluphenazine is not approved for use by anyone younger than 12 years old.

Using antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn. If you get pregnant, tell your doctor right away. Do not stop using fluphenazine without your doctor's advice.

Fluphenazine may cause false results on a pregnancy test. Tell your doctor if you think you might be pregnant.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

How should I use fluphenazine (Permitil, Prolixin, Prolixin Decanoate)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Fluphenazine oral is taken by mouth.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Fluphenazine oral concentrate solution must be mixed with at least 2 ounces (1/4 cup) of a liquid such as milk, tomato juice, fruit juice (but not apple juice), or a soft drink that does not contain caffeine.

Fluphenazine injection is injected into a muscle or under the skin by a healthcare provider. Fluphenazine is usually given by injection only after you have taken the medicine by mouth for a certain period of time.

Fluphenazine injection stays in your body longer than the oral form, and the injections are not given daily. Follow your doctor's dosing instructions very carefully.

You may need frequent medical tests. Your next dose may be delayed based on the results.

If you need surgery, tell the surgeon ahead of time that you are using fluphenazine.

Do not stop using fluphenazine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Store at room temperature away from moisture, heat, and light. Do not allow liquid medicine to freeze.


Schizophrenia is the most disabling mental illness. See Answer

What happens if I miss a dose (Permitil, Prolixin, Prolixin Decanoate)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Call your doctor for instructions if you miss an appointment for your fluphenazine injection.

What happens if I overdose (Permitil, Prolixin, Prolixin Decanoate)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using fluphenazine (Permitil, Prolixin, Prolixin Decanoate)?

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Drinking alcohol with this medicine can cause side effects.

Fluphenazine could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What other drugs will affect fluphenazine (Permitil, Prolixin, Prolixin Decanoate)?

Using fluphenazine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Other drugs may affect fluphenazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information (Permitil, Prolixin, Prolixin Decanoate)?

Your pharmacist can provide more information about fluphenazine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Reviewed on 10/12/2022

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