gadoversetamide (OptiMARK)

Brand Names: OptiMARK

Generic Name: gadoversetamide

What is gadoversetamide (OptiMARK)?

Gadoversetamide is a contrast agent with magnetic properties. It is used in combination with magnetic resonance imagining (MRI) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on the MRI.

Gadoversetamide is used to help diagnose certain disorders of the brain and spine (central nervous system), or the liver.

Gadoversetamide may also be used for purposes not listed in this medication guide.

What are the possible side effects of gadoversetamide (OptiMARK)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects of gadoversetamide may occur up to several days after injection.

Gadoversetamide can cause a life-threatening condition in people with advanced kidney disease. Call your doctor right away if you have any symptoms of this condition, such as:

  • burning, itching, swelling, scaling, and tightening or hardening of your skin;
  • muscle weakness;
  • joint stiffness in your arms, hands, legs, or feet;
  • deep bone pain in your ribs or your hips;
  • trouble moving; or
  • skin redness or discoloration.

Also call your doctor at once if you have:

  • kidney problems--little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath;
  • a seizure (convulsions); or
  • fast, uneven heart rate.

Common side effects may include:

  • headache, dizziness;
  • nausea;
  • flushing (warmth, redness, or tingly feeling);
  • unusual or unpleasant taste in your mouth; or
  • numbness, burning pain, or tingling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about gadoversetamide (OptiMARK)?

Gadoversetamide can cause a life-threatening condition in people with advanced kidney disease. You should not receive this medication if you have kidney disease or if you are on dialysis.

What should I discuss with my healthcare provider before receiving gadoversetamide (OptiMARK)?

Gadoversetamide can cause a life-threatening condition in people with advanced kidney disease. You should not receive this medication if you have kidney disease or if you are on dialysis.

Gadoversetamide can stay in your body for months or years after you receive this medicine. It is not known whether this could cause any health problems in people whose kidneys work properly. Tell your doctor if you have had repeated scans with a contrast agent, and provide the date of your last scan.

You should not receive gadoversetamide if you are allergic to it.

Tell your doctor if you have ever had:

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

Do not breast-feed for at least 72 hours after receiving gadoversetamide. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

How is gadoversetamide given (OptiMARK)?

Gadoversetamide is given as an infusion into a vein. A healthcare provider will give you this injection.

Your doctor or other healthcare provider may want to watch you for a short time after your test is over. This is to make sure you do not have any unwanted side effects or delayed reactions.

Gadoversetamide can affect the results of certain medical tests for up to 24 hours after your MRI. Tell any doctor who treats you that you have received gadoversetamide.

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What happens if I miss a dose (OptiMARK)?

Since gadoversetamide is used only during your MRI, you will not be on a dosing schedule.

What happens if I overdose (OptiMARK)?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving gadoversetamide (OptiMARK)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect gadoversetamide (OptiMARK)?

Other drugs may affect gadoversetamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information (OptiMARK)?

Your doctor or pharmacist can provide more information about gadoversetamide.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Reviewed on 7/12/2021

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